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- W4237820904 abstract "The aging of organisms is accompanied by dramatic changes in the cellular concentration of metal ions. Much evidence indicates that aging is genetically determined. Since genetic information transfer processes require metal ions in suitable concentrations, and since excess metal ions produce errors in information transfer, it is reasonable to expect that the age changes in metal concentrations affect the aging process. Metal ions can induce the mispairing of nucleotide bases and the incorporation of the wrong amino acids into proteins; this phenomenon has been used to probe old and young rat liver ribosomes to determine whether any changes in fidelity of translation have taken place. Evidence has been obtained for an age change in chromatin structure that is associated with metal binding. There is good evidence that localized accumulations of aluminum in the brain accompany Alzheimer's disease, the most prevalent form of senile dementia (2). Aluminum concentrates in the cellular chromatin, and in a pH-dependent reaction can either stabilize or destabilize the DNA double helix. Stabilization appears to result from the binding of A1(OH)2+ to DNA, and destabilization from the binding of A13+. The latter forms crosslinks between DNA strands; crosslink formation can be reversed by sequestering the aluminum with EDTA." @default.
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- W4237820904 date "1980-12-22" @default.
- W4237820904 modified "2023-09-27" @default.
- W4237820904 title "Metal Ion—Nucleic Acid Interactions" @default.
- W4237820904 doi "https://doi.org/10.1021/bk-1980-0140.ch004" @default.
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