FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237886169> ?p ?o ?g. }

• W4237886169 abstract "Abstract Background WHO recommends RDTs as a good alternative malaria-diagnosis method in remote parts of sub-Saharan Africa. The majority of commercial RDTs currently available detect the P. falciparum protein histidine-rich protein 2 (PfHRP2). There have also been recent reports of Pfhrp2 deletions being found in parasites collected from several African countries. WHO has concluded that the lacking the Pfhrp2 gene must be monitored in Africa. The purpose of the study was to analyze why the samples that were positive by PCR were negative by RDTs; and, therefore, to determine whether there have been deletions in the Pfhrp2 and/or Pfhrp3 genes. Methods Malaria NM-PCR was carried out to all the samples collected in the field. A group of 128 samples was positive by PCR but negatives by RDT, these samples were classified as RDT false-negatives. It was carried out a PCR for exon2 of Pfhrp2 and Pfhrp3 genes to detect the presence or absence of these two genes. Frequencies with 95% confidence intervals (CIs) were used for prevalence estimates. Associations were assessed by the chi-square test or Fisher´s exact test. The level of significance was set at p ≤ 0.05. Statistical analyses were performed using the software package SPSSv.15.0. Results After the PCR, 81 samples were identified (4.7%, 95%CI: 3.8-5.8) which had deletion in both genes, Pfhrp2 and Pfhrp3 . Overall, however, 11 samples (0.6%, 95%CI: 0.36-1.14) had deletion only in Pfhrp2 but not in Pfhrp3 , and 15 (0.9%, 95%CI: 0.6-1.5) presented with deletion only in Pfhrp3 but not in Pfhrp2 . Considering the Pfhrp2 gene separately, within the total of 1,724 samples, 92 (5.3%, 95%CI: 4.37-6.5) had evidence of deletion. Conclusion The present study provides the first evidence of deletion in the Pfhrp2 and Pfhrp3 genes in P. falciparum isolates from Equatorial Guinea. However, larger studies across different regions within the country and across different seasonal profiles are needed to determine the full extent of Pfhrp2 and Pfhrp3 deletion. It would be strongly recommendable to implement an active surveillance program in order to detect any increases in Pfhrp2 and Pfhrp3 deletion frequencies." @default.
• W4237886169 created "2022-05-12" @default.
• W4237886169 creator A5006503984 @default.
• W4237886169 creator A5019715163 @default.
• W4237886169 creator A5051263658 @default.
• W4237886169 creator A5053440389 @default.
• W4237886169 creator A5053704634 @default.
• W4237886169 creator A5054836364 @default.
• W4237886169 creator A5061858171 @default.
• W4237886169 creator A5067529107 @default.
• W4237886169 creator A5089887602 @default.
• W4237886169 date "2020-01-20" @default.
• W4237886169 modified "2023-10-17" @default.
• W4237886169 title "First evidence of the deletion in the Pfhrp2 and Pfhrp3 genes in P. falciparum from Equatorial Guinea" @default.
• W4237886169 doi "https://doi.org/10.21203/rs.2.17607/v2" @default.
• W4237886169 hasPublicationYear "2020" @default.
• W4237886169 type Work @default.
• W4237886169 citedByCount "0" @default.
• W4237886169 crossrefType "posted-content" @default.
• W4237886169 hasAuthorship W4237886169A5006503984 @default.
• W4237886169 hasAuthorship W4237886169A5019715163 @default.
• W4237886169 hasAuthorship W4237886169A5051263658 @default.
• W4237886169 hasAuthorship W4237886169A5053440389 @default.
• W4237886169 hasAuthorship W4237886169A5053704634 @default.
• W4237886169 hasAuthorship W4237886169A5054836364 @default.
• W4237886169 hasAuthorship W4237886169A5061858171 @default.
• W4237886169 hasAuthorship W4237886169A5067529107 @default.
• W4237886169 hasAuthorship W4237886169A5089887602 @default.
• W4237886169 hasBestOaLocation W42378861691 @default.
• W4237886169 hasConcept C104317684 @default.
• W4237886169 hasConcept C126322002 @default.
• W4237886169 hasConcept C136764020 @default.
• W4237886169 hasConcept C159047783 @default.
• W4237886169 hasConcept C203014093 @default.
• W4237886169 hasConcept C2778048844 @default.
• W4237886169 hasConcept C2778371730 @default.
• W4237886169 hasConcept C41008148 @default.
• W4237886169 hasConcept C44249647 @default.
• W4237886169 hasConcept C54355233 @default.
• W4237886169 hasConcept C71924100 @default.
• W4237886169 hasConcept C71928629 @default.
• W4237886169 hasConcept C86803240 @default.
• W4237886169 hasConceptScore W4237886169C104317684 @default.
• W4237886169 hasConceptScore W4237886169C126322002 @default.
• W4237886169 hasConceptScore W4237886169C136764020 @default.
• W4237886169 hasConceptScore W4237886169C159047783 @default.
• W4237886169 hasConceptScore W4237886169C203014093 @default.
• W4237886169 hasConceptScore W4237886169C2778048844 @default.
• W4237886169 hasConceptScore W4237886169C2778371730 @default.
• W4237886169 hasConceptScore W4237886169C41008148 @default.
• W4237886169 hasConceptScore W4237886169C44249647 @default.
• W4237886169 hasConceptScore W4237886169C54355233 @default.
• W4237886169 hasConceptScore W4237886169C71924100 @default.
• W4237886169 hasConceptScore W4237886169C71928629 @default.
• W4237886169 hasConceptScore W4237886169C86803240 @default.
• W4237886169 hasLocation W42378861691 @default.
• W4237886169 hasLocation W42378861692 @default.
• W4237886169 hasLocation W42378861693 @default.
• W4237886169 hasOpenAccess W4237886169 @default.
• W4237886169 hasPrimaryLocation W42378861691 @default.
• W4237886169 hasRelatedWork W1497193691 @default.
• W4237886169 hasRelatedWork W2223558987 @default.
• W4237886169 hasRelatedWork W2331540016 @default.
• W4237886169 hasRelatedWork W4233954877 @default.
• W4237886169 hasRelatedWork W4242100056 @default.
• W4237886169 hasRelatedWork W4247344263 @default.
• W4237886169 hasRelatedWork W4248815392 @default.
• W4237886169 hasRelatedWork W4299839590 @default.
• W4237886169 hasRelatedWork W4301083242 @default.
• W4237886169 hasRelatedWork W4301259516 @default.
• W4237886169 isParatext "false" @default.
• W4237886169 isRetracted "false" @default.
• W4237886169 workType "article" @default.