Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237908197> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4237908197 endingPage "263" @default.
- W4237908197 startingPage "255" @default.
- W4237908197 abstract "Adult male CrlCD:BR rats were exposed nose-only to several concentrations of dimethyl sulfate (DMS) vapors to determine the relationships between vapor uptake and DNA methylation. Following DMS exposure, nasal respiratory and olfactory mucosa and lung tissue were removed and DNA was isolated for the analysis of methylated purines. DMS vapor uptake was complex and related to exposure concentration; clearance appeared to increase with increasing DMS concentrations between 0.5 and 8 ppm. Plethysmorgraphic measurements correlated with the time-dependent disappearance of dimethyl sulfate from a closed exposure apparatus. Above an initial DMS concentration of 8 ppm, sensory irritancy apparently altered normal respiratory parameters, clearance, and regional DNA methylation. DMS-dependent N7-methylguanine formation in DNA isolated from nasal respiratory mucosa was detectable 30 mm following a 20-min exposure to an initial DMS concentration of 1 ppm. DMS-dependent methylation of DNA, as evidenced by N7-methylguanine and N3-methyladenine formation, showed concentration-response relationships in all tissues examined and was correlated with vapor uptake. DNA adduct formation showed regional differences characteristic of the absorption of a water-soluble vapor; methylation was greatest in DNA isolated from respiratory mucosa, less in olfactory, and little in lung. Repair of N7-methylguanine did not appear to be significantly different between nasal respiratory and olfactory tissues. These experiments demonstrate that DMS is a potent methylating agent of nasal mucosa in vivo." @default.
- W4237908197 created "2022-05-12" @default.
- W4237908197 creator A5015420033 @default.
- W4237908197 creator A5059289128 @default.
- W4237908197 creator A5065611085 @default.
- W4237908197 date "1995-01-01" @default.
- W4237908197 modified "2023-10-18" @default.
- W4237908197 title "Dimethyl Sulfate Uptake and Methylation of DNA in Rat Respiratory Tissues Following Acute Inhalation" @default.
- W4237908197 doi "https://doi.org/10.1093/toxsci/28.2.255" @default.
- W4237908197 hasPublicationYear "1995" @default.
- W4237908197 type Work @default.
- W4237908197 citedByCount "1" @default.
- W4237908197 countsByYear W42379081972015 @default.
- W4237908197 crossrefType "journal-article" @default.
- W4237908197 hasAuthorship W4237908197A5015420033 @default.
- W4237908197 hasAuthorship W4237908197A5059289128 @default.
- W4237908197 hasAuthorship W4237908197A5065611085 @default.
- W4237908197 hasConcept C104317684 @default.
- W4237908197 hasConcept C105702510 @default.
- W4237908197 hasConcept C114246631 @default.
- W4237908197 hasConcept C150194340 @default.
- W4237908197 hasConcept C150903083 @default.
- W4237908197 hasConcept C153911025 @default.
- W4237908197 hasConcept C169760540 @default.
- W4237908197 hasConcept C170493617 @default.
- W4237908197 hasConcept C178790620 @default.
- W4237908197 hasConcept C185592680 @default.
- W4237908197 hasConcept C190727270 @default.
- W4237908197 hasConcept C201792869 @default.
- W4237908197 hasConcept C203014093 @default.
- W4237908197 hasConcept C207001950 @default.
- W4237908197 hasConcept C2776954882 @default.
- W4237908197 hasConcept C2778801703 @default.
- W4237908197 hasConcept C2779193700 @default.
- W4237908197 hasConcept C2779777708 @default.
- W4237908197 hasConcept C2780187430 @default.
- W4237908197 hasConcept C2781377823 @default.
- W4237908197 hasConcept C2910059436 @default.
- W4237908197 hasConcept C29730261 @default.
- W4237908197 hasConcept C33288867 @default.
- W4237908197 hasConcept C534529494 @default.
- W4237908197 hasConcept C552990157 @default.
- W4237908197 hasConcept C55493867 @default.
- W4237908197 hasConcept C59377437 @default.
- W4237908197 hasConcept C86803240 @default.
- W4237908197 hasConceptScore W4237908197C104317684 @default.
- W4237908197 hasConceptScore W4237908197C105702510 @default.
- W4237908197 hasConceptScore W4237908197C114246631 @default.
- W4237908197 hasConceptScore W4237908197C150194340 @default.
- W4237908197 hasConceptScore W4237908197C150903083 @default.
- W4237908197 hasConceptScore W4237908197C153911025 @default.
- W4237908197 hasConceptScore W4237908197C169760540 @default.
- W4237908197 hasConceptScore W4237908197C170493617 @default.
- W4237908197 hasConceptScore W4237908197C178790620 @default.
- W4237908197 hasConceptScore W4237908197C185592680 @default.
- W4237908197 hasConceptScore W4237908197C190727270 @default.
- W4237908197 hasConceptScore W4237908197C201792869 @default.
- W4237908197 hasConceptScore W4237908197C203014093 @default.
- W4237908197 hasConceptScore W4237908197C207001950 @default.
- W4237908197 hasConceptScore W4237908197C2776954882 @default.
- W4237908197 hasConceptScore W4237908197C2778801703 @default.
- W4237908197 hasConceptScore W4237908197C2779193700 @default.
- W4237908197 hasConceptScore W4237908197C2779777708 @default.
- W4237908197 hasConceptScore W4237908197C2780187430 @default.
- W4237908197 hasConceptScore W4237908197C2781377823 @default.
- W4237908197 hasConceptScore W4237908197C2910059436 @default.
- W4237908197 hasConceptScore W4237908197C29730261 @default.
- W4237908197 hasConceptScore W4237908197C33288867 @default.
- W4237908197 hasConceptScore W4237908197C534529494 @default.
- W4237908197 hasConceptScore W4237908197C552990157 @default.
- W4237908197 hasConceptScore W4237908197C55493867 @default.
- W4237908197 hasConceptScore W4237908197C59377437 @default.
- W4237908197 hasConceptScore W4237908197C86803240 @default.
- W4237908197 hasIssue "2" @default.
- W4237908197 hasLocation W42379081971 @default.
- W4237908197 hasOpenAccess W4237908197 @default.
- W4237908197 hasPrimaryLocation W42379081971 @default.
- W4237908197 hasRelatedWork W1983644056 @default.
- W4237908197 hasRelatedWork W1994613283 @default.
- W4237908197 hasRelatedWork W2010196563 @default.
- W4237908197 hasRelatedWork W2011170732 @default.
- W4237908197 hasRelatedWork W2121562745 @default.
- W4237908197 hasRelatedWork W2141002745 @default.
- W4237908197 hasRelatedWork W2154207808 @default.
- W4237908197 hasRelatedWork W2163020484 @default.
- W4237908197 hasRelatedWork W2396462818 @default.
- W4237908197 hasRelatedWork W4288052516 @default.
- W4237908197 hasVolume "28" @default.
- W4237908197 isParatext "false" @default.
- W4237908197 isRetracted "false" @default.
- W4237908197 workType "article" @default.