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- W4237942327 abstract "O'Brien and his colleagues<sup>1</sup>recently reported on a review of the world literature on alkaptonuria, ochronosis, and ochronotic arthropathy. In 1859, Boedeker first used the word alkapton to describe a reducing substance in the urine of certain patients which had a strong affinity for alkali and caused the urine to become dark brown on standing. The reducing substance was later identified as homogentisic acid by Wolkow and Bauman in 1891. Virchow introduced the term ochronosis in 1866 to indicate a clinical disease seen in many young alkaptonuric patients. It was not until 1902 that Albrecht first realized that the three conditions were all various stages of the same disease entity. Alkaptonuria is an inborn error of metabolism usually inherited as an autosomal recessive gene. There is a wide geographic and racial distribution, but O'Brien and co-workers<sup>1</sup>noted it especially in areas where there is a high incidence of" @default.
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- W4237942327 date "1970-02-01" @default.
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- W4237942327 title "Ochronotic Arthropathy" @default.
- W4237942327 doi "https://doi.org/10.1001/archsurg.1970.01340200103023" @default.
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