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- W4237947768 abstract "Trypanosomatids are ancient unicellular eukaryotes that parasitize different invertebrates and mammals, producing deadly diseases and economic losses. During their complex life cycle the parasites differentiate, stimulated by and to withstand different, physicochemical, biochemical, and biological stresses. Differentiation is characterized by important structural reorganizations and by the loss and gain of metabolic functions, among other processes. A genetic hallmark of trypanosomatids is that gene expression is mostly controlled at the posttranscriptional level. This renders posttranslational (redox) modifications as key mechanisms to rapidly modulate protein activity. In fact, changes in the level of reactive species derived from the partial reduction of oxygen or from nitric oxide, either produced by their hosts or endogenously, act as signals that (in)activate different cellular processes (e.g., proliferation, differentiation, and virulence). In this respect, the thiol-disulphide redox system is of paramount relevance to achieve specificity (e.g., molecular target and compartmentalization) and kinetic control along the signalling cascade. The redox system of trypanosomatids is unique and presents a minimalistic configuration, compared to the more sophisticated and redundant systems present in mammals. This chapter analyses some of the biological processes of trypanosomatids that are subject to redox signalling and control by the parasite thiol-disulphide redox system." @default.
- W4237947768 created "2022-05-12" @default.
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- W4237947768 date "2021-08-26" @default.
- W4237947768 modified "2023-09-29" @default.
- W4237947768 title "Thiol-Disulphide Redox Signalling/Control during the Life Cycle of Pathogenic Trypanosomatids" @default.
- W4237947768 doi "https://doi.org/10.1201/9781003204091-5" @default.
- W4237947768 hasPublicationYear "2021" @default.
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