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- W4238012512 abstract "Sphingofungins are a family of natural products with potent antifungal properties, isolated by Merck group from the fermentation of Paecilomyces variotii in 1992. The sphingofungins possess unique polyhydroxyamino acid moiety and long lipid chain and are like sphingosine compounds that inhibit serine palmitoyltransferase, an enzyme used in the initial step of sphingolipid biosynthesis. The sphingofungins E and F bear quaternary center along with trans double bond in polyhydroxy amine scaffold and have antifungal activities against several human pathogenic fungi. The significant biological properties with interesting structural features, i.e., presence of α-substituted α-amino acid with trihydroxy alkylated chain make them interesting target for synthesis chemists." @default.
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- W4238012512 date "2021-01-01" @default.
- W4238012512 modified "2023-10-06" @default.
- W4238012512 title "Sphingofungins" @default.
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- W4238012512 doi "https://doi.org/10.1016/b978-0-12-822262-1.00010-x" @default.
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