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- W4238012735 abstract "Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase in basement membrane bridges is observed. Using cell-specific markers, we demonstrate that pericytes rather than endothelial cells colocalize with these bridges. We show that the density of bridges transiently increases with elevation of Ang-2, PDGF-BB, and blood sugar, is rapidly reversed on a time scale of days, and often associated with a pericyte cell body located off-vessel. Cell-specific knockout of KLF4 in pericytes fully replicates this phenotype. <i>In vivo</i> imaging of limbal vessels demonstrates pericyte migration off-vessel, with rapid pericyte filopodial-like process formation between adjacent vessels. Accounting for off-vessel and on-vessel pericytes, we observe no pericyte loss relative to non-diabetic control retina. These findings reveal the possibility that pericyte perturbations in location and process formation may play a role in the development of pathological vascular remodeling in diabetic retinopathy." @default.
- W4238012735 created "2022-05-12" @default.
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- W4238012735 date "2020-04-22" @default.
- W4238012735 modified "2023-10-14" @default.
- W4238012735 title "Pericyte Bridges in Homeostasis and Hyperglycemia" @default.
- W4238012735 doi "https://doi.org/10.2337/figshare.12145425.v1" @default.
- W4238012735 hasPublicationYear "2020" @default.
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