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- W4238021243 abstract "Abstract This study describes the strong anti-CRISPR activity of the bacterial AcrIIA4 protein in Nicotiana benthamiana , a model plant used as molecular farming platform. The results demonstrate that AcrIIA4 abolishes site-directed mutagenesis in leaves when transiently co-expressed with CRISPR/Cas9. We also show that AcrIIA4 represses CRISPR/dCas9-based transcriptional activation (CRISPRa) of both reporter and endogenous genes in a highly efficient, dose-dependent manner. Furthermore, the fusion of an auxin degron to AcrIIA4 results in auxin-regulated activation of a downstream reporter gene. The strong anti-Cas9 activity of AcrIIA4 reported here opens new possibilities for customized control of gene editing and gene expression in plants." @default.
- W4238021243 created "2022-05-12" @default.
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- W4238021243 date "2021-01-08" @default.
- W4238021243 modified "2023-09-24" @default.
- W4238021243 title "Strong and tunable anti-CRISPR/Cas9 activity of AcrIIA4 in plants" @default.
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- W4238021243 doi "https://doi.org/10.1101/2021.01.08.425920" @default.
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