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- W4238027673 abstract "The pattern of replication of DNA was studied using a quadruple auxotroph of Escherichia coli requiring thymine, methionine, arginine, and tryptophan. Cells were labelled with a pulse of tritiated thymine and then grown in bromouracil medium either immediately or after an intervening period of amino acid starvation. The patterns of conversion of light-radioactive into hybrid-radioactive DNA under these different conditions provide evidence that a sequential pattern of replication for the bacterial chromosome exists. Prolonged amino acid deprivation was shown to align the DNA replication cycles of individual cells. However, that DNA which is replicated in the absence of amino acids is abnormal. It is subsequently replicated at a slower rate than the DNA normally made in the presence of amino acids." @default.
- W4238027673 created "2022-05-12" @default.
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- W4238027673 date "1963-01-01" @default.
- W4238027673 modified "2023-10-17" @default.
- W4238027673 title "The effect of amino acid deprivation on subsequent deoxyribonucleic acid replication" @default.
- W4238027673 doi "https://doi.org/10.1016/0926-6569(63)90003-3" @default.
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