FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238040639> ?p ?o ?g. }

• W4238040639 endingPage "225" @default.
• W4238040639 startingPage "217" @default.
• W4238040639 abstract "The role of ceramide as a second messenger is a subject of great interest, particularly since it is implicated in signaling in response to inflammatory cytokines. Ceramide induces apoptosis in both cytokine-dependent MC/9 cells and factor-independent U937 cells. Elevation of cyclic adenosine monophosphate (cAMP) levels inhibits apoptosis induced by ceramide and several other treatments. One target of cAMP-mediated signaling is the transcription factor CREB (cAMP response element binding protein), and recently CREB phosphorylation at an activating site has been shown to also be mediated by a cascade involving p38 mitogen-activated protein kinase (MAPK), one of the stress-activated MAP kinases. Because no role for p38 MAPK in apoptosis has been firmly established, we examined the relationship between p38 MAPK and CREB phosphorylation under various conditions. Ceramide, or sphingomyelinase, like tumor necrosis factor- (TNF-) or the hematopoietic growth factor, interleukin-3 (IL-3), was shown to activate p38 MAPK, which in turn activated MAPKAP kinase-2. Each of these treatments led to phosphorylation of CREB (and the related factor ATF-1). A selective p38 MAPK inhibitor, SB203580, blocked TNF-– or ceramide-induced CREB phosphorylation, but had no effect on the induction of apoptosis mediated by these agents. The protective agents cAMP and IL-3 also led to CREB phosphorylation, but this effect was independent of p38 MAPK, even though IL-3 was shown to activate both p38 MAPK and MAPKAP kinase-2. Therefore, the opposing effects on apoptosis observed with cAMP and IL-3, compared with ceramide and TNF-, could not be explained on the basis of phosphorylation of CREB. In addition, because SB203580 had no effect of TNF- or ceramide-induced apoptosis, our results strongly argue against a role for p38 MAPK in the induction of TNF-– or ceramide-induced apoptosis." @default.
• W4238040639 created "2022-05-12" @default.
• W4238040639 creator A5034901985 @default.
• W4238040639 creator A5050259451 @default.
• W4238040639 creator A5050668557 @default.
• W4238040639 creator A5053999665 @default.
• W4238040639 creator A5076433485 @default.
• W4238040639 date "1999-01-01" @default.
• W4238040639 modified "2023-10-01" @default.
• W4238040639 title "Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival" @default.
• W4238040639 cites W1520176015 @default.
• W4238040639 cites W1536331044 @default.
• W4238040639 cites W1560653098 @default.
• W4238040639 cites W1964100540 @default.
• W4238040639 cites W1964788380 @default.
• W4238040639 cites W1969158591 @default.
• W4238040639 cites W1975499205 @default.
• W4238040639 cites W1978048485 @default.
• W4238040639 cites W1987931310 @default.
• W4238040639 cites W1989710374 @default.
• W4238040639 cites W1998448534 @default.
• W4238040639 cites W1999012962 @default.
• W4238040639 cites W2005350675 @default.
• W4238040639 cites W2030900078 @default.
• W4238040639 cites W2032731042 @default.
• W4238040639 cites W2043094358 @default.
• W4238040639 cites W2043395027 @default.
• W4238040639 cites W2043775652 @default.
• W4238040639 cites W2047682144 @default.
• W4238040639 cites W2048121649 @default.
• W4238040639 cites W2049377259 @default.
• W4238040639 cites W2065257477 @default.
• W4238040639 cites W2070005836 @default.
• W4238040639 cites W2077156149 @default.
• W4238040639 cites W2080475643 @default.
• W4238040639 cites W2081524299 @default.
• W4238040639 cites W2092330976 @default.
• W4238040639 cites W2093676869 @default.
• W4238040639 cites W2101950406 @default.
• W4238040639 cites W2124657439 @default.
• W4238040639 cites W2135687585 @default.
• W4238040639 cites W2135935249 @default.
• W4238040639 cites W2147678437 @default.
• W4238040639 cites W2174898638 @default.
• W4238040639 cites W2395274642 @default.
• W4238040639 cites W4255402549 @default.
• W4238040639 doi "https://doi.org/10.1182/blood.v93.1.217.401k16_217_225" @default.
• W4238040639 hasPublicationYear "1999" @default.
• W4238040639 type Work @default.
• W4238040639 citedByCount "3" @default.
• W4238040639 crossrefType "journal-article" @default.
• W4238040639 hasAuthorship W4238040639A5034901985 @default.
• W4238040639 hasAuthorship W4238040639A5050259451 @default.
• W4238040639 hasAuthorship W4238040639A5050668557 @default.
• W4238040639 hasAuthorship W4238040639A5053999665 @default.
• W4238040639 hasAuthorship W4238040639A5076433485 @default.
• W4238040639 hasConcept C104317684 @default.
• W4238040639 hasConcept C11960822 @default.
• W4238040639 hasConcept C1629964 @default.
• W4238040639 hasConcept C170493617 @default.
• W4238040639 hasConcept C180899940 @default.
• W4238040639 hasConcept C185592680 @default.
• W4238040639 hasConcept C190283241 @default.
• W4238040639 hasConcept C2776668983 @default.
• W4238040639 hasConcept C2777851122 @default.
• W4238040639 hasConcept C51551487 @default.
• W4238040639 hasConcept C55493867 @default.
• W4238040639 hasConcept C57074206 @default.
• W4238040639 hasConcept C62478195 @default.
• W4238040639 hasConcept C86339819 @default.
• W4238040639 hasConcept C86803240 @default.
• W4238040639 hasConcept C95444343 @default.
• W4238040639 hasConcept C97029542 @default.
• W4238040639 hasConceptScore W4238040639C104317684 @default.
• W4238040639 hasConceptScore W4238040639C11960822 @default.
• W4238040639 hasConceptScore W4238040639C1629964 @default.
• W4238040639 hasConceptScore W4238040639C170493617 @default.
• W4238040639 hasConceptScore W4238040639C180899940 @default.
• W4238040639 hasConceptScore W4238040639C185592680 @default.
• W4238040639 hasConceptScore W4238040639C190283241 @default.
• W4238040639 hasConceptScore W4238040639C2776668983 @default.
• W4238040639 hasConceptScore W4238040639C2777851122 @default.
• W4238040639 hasConceptScore W4238040639C51551487 @default.
• W4238040639 hasConceptScore W4238040639C55493867 @default.
• W4238040639 hasConceptScore W4238040639C57074206 @default.
• W4238040639 hasConceptScore W4238040639C62478195 @default.
• W4238040639 hasConceptScore W4238040639C86339819 @default.
• W4238040639 hasConceptScore W4238040639C86803240 @default.
• W4238040639 hasConceptScore W4238040639C95444343 @default.
• W4238040639 hasConceptScore W4238040639C97029542 @default.
• W4238040639 hasIssue "1" @default.
• W4238040639 hasLocation W42380406391 @default.
• W4238040639 hasOpenAccess W4238040639 @default.
• W4238040639 hasPrimaryLocation W42380406391 @default.
• W4238040639 hasRelatedWork W13822107 @default.
• W4238040639 hasRelatedWork W1936681 @default.
• W4238040639 hasRelatedWork W22357311 @default.
• W4238040639 hasRelatedWork W23025822 @default.

• next