FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238041337> ?p ?o ?g. }

• W4238041337 endingPage "7676" @default.
• W4238041337 startingPage "7666" @default.
• W4238041337 abstract "The gene for the iron-binding protein transferrin is transcribed at a high level in liver hepatocytes but is also active in several other cell types, including oligodendrocytes in the brain. Enhancer elements between bp -560 and -44 of the transferrin gene promoter specifically activated transcription from a heterologous promoter in transgenic mouse liver and brain. Within this region, a potent cis-acting element between bp -98 and -83 was found to be essential for gene activity in both cultured hepatocytes and transgenic mouse liver. The -98 to -83 element contains a CCAAT sequence and is specifically bound by a nuclear factor from mouse liver that is homologous to rat liver C/EBP (CAAT enhancer-binding protein). Point mutations within this binding site inhibit factor binding and abolish transcription in transfected hepatoma cells. When placed in the context of the 3,000-bp transferrin promoter, the C/EBP binding site mutation causes a complete loss of transcription in transgenic mouse liver; however, transgene expression in the brain of the same animals was unaffected. These results suggest a modular structure for the transferrin promoter and demonstrate that deletions or specific point mutations can be used to generate transgene promoters with an activity more restricted than that of their endogenous counterparts." @default.
• W4238041337 created "2022-05-12" @default.
• W4238041337 creator A5017044526 @default.
• W4238041337 creator A5024806489 @default.
• W4238041337 creator A5044563402 @default.
• W4238041337 creator A5080788580 @default.
• W4238041337 creator A5089013559 @default.
• W4238041337 date "1993-12-01" @default.
• W4238041337 modified "2023-09-24" @default.
• W4238041337 title "A C/EBP-binding site in the transferrin promoter is essential for expression in the liver but not the brain of transgenic mice" @default.
• W4238041337 cites W1480192557 @default.
• W4238041337 cites W1483742682 @default.
• W4238041337 cites W1492249156 @default.
• W4238041337 cites W1493312303 @default.
• W4238041337 cites W1502467522 @default.
• W4238041337 cites W1529055053 @default.
• W4238041337 cites W1557592212 @default.
• W4238041337 cites W1584396549 @default.
• W4238041337 cites W1607832336 @default.
• W4238041337 cites W1660497171 @default.
• W4238041337 cites W1980129974 @default.
• W4238041337 cites W1985051242 @default.
• W4238041337 cites W1988059168 @default.
• W4238041337 cites W1993243592 @default.
• W4238041337 cites W1996261926 @default.
• W4238041337 cites W1997094462 @default.
• W4238041337 cites W2002935828 @default.
• W4238041337 cites W2005019916 @default.
• W4238041337 cites W2007510308 @default.
• W4238041337 cites W2008714893 @default.
• W4238041337 cites W2009046213 @default.
• W4238041337 cites W2019088616 @default.
• W4238041337 cites W2020274565 @default.
• W4238041337 cites W2021563901 @default.
• W4238041337 cites W2035416523 @default.
• W4238041337 cites W2036553614 @default.
• W4238041337 cites W2045040663 @default.
• W4238041337 cites W2049395473 @default.
• W4238041337 cites W2058023750 @default.
• W4238041337 cites W2059000943 @default.
• W4238041337 cites W2064541600 @default.
• W4238041337 cites W2066215499 @default.
• W4238041337 cites W2066872253 @default.
• W4238041337 cites W2072881211 @default.
• W4238041337 cites W2081631093 @default.
• W4238041337 cites W2102950226 @default.
• W4238041337 cites W2111597989 @default.
• W4238041337 cites W2114683402 @default.
• W4238041337 cites W2116478928 @default.
• W4238041337 cites W2126093778 @default.
• W4238041337 cites W2129346720 @default.
• W4238041337 cites W2135374851 @default.
• W4238041337 cites W2136066768 @default.
• W4238041337 cites W2167150297 @default.
• W4238041337 cites W2168415166 @default.
• W4238041337 cites W2170005346 @default.
• W4238041337 cites W2235991681 @default.
• W4238041337 doi "https://doi.org/10.1128/mcb.13.12.7666-7676.1993" @default.
• W4238041337 hasPublicationYear "1993" @default.
• W4238041337 type Work @default.
• W4238041337 citedByCount "0" @default.
• W4238041337 crossrefType "journal-article" @default.
• W4238041337 hasAuthorship W4238041337A5017044526 @default.
• W4238041337 hasAuthorship W4238041337A5024806489 @default.
• W4238041337 hasAuthorship W4238041337A5044563402 @default.
• W4238041337 hasAuthorship W4238041337A5080788580 @default.
• W4238041337 hasAuthorship W4238041337A5089013559 @default.
• W4238041337 hasConcept C101762097 @default.
• W4238041337 hasConcept C102230213 @default.
• W4238041337 hasConcept C104317684 @default.
• W4238041337 hasConcept C107824862 @default.
• W4238041337 hasConcept C111936080 @default.
• W4238041337 hasConcept C138885662 @default.
• W4238041337 hasConcept C149240914 @default.
• W4238041337 hasConcept C150194340 @default.
• W4238041337 hasConcept C153911025 @default.
• W4238041337 hasConcept C176944494 @default.
• W4238041337 hasConcept C179926584 @default.
• W4238041337 hasConcept C21592294 @default.
• W4238041337 hasConcept C22814914 @default.
• W4238041337 hasConcept C29512474 @default.
• W4238041337 hasConcept C41895202 @default.
• W4238041337 hasConcept C501734568 @default.
• W4238041337 hasConcept C54355233 @default.
• W4238041337 hasConcept C55493867 @default.
• W4238041337 hasConcept C86339819 @default.
• W4238041337 hasConcept C86803240 @default.
• W4238041337 hasConceptScore W4238041337C101762097 @default.
• W4238041337 hasConceptScore W4238041337C102230213 @default.
• W4238041337 hasConceptScore W4238041337C104317684 @default.
• W4238041337 hasConceptScore W4238041337C107824862 @default.
• W4238041337 hasConceptScore W4238041337C111936080 @default.
• W4238041337 hasConceptScore W4238041337C138885662 @default.
• W4238041337 hasConceptScore W4238041337C149240914 @default.
• W4238041337 hasConceptScore W4238041337C150194340 @default.
• W4238041337 hasConceptScore W4238041337C153911025 @default.
• W4238041337 hasConceptScore W4238041337C176944494 @default.
• W4238041337 hasConceptScore W4238041337C179926584 @default.

• next