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- W4238052140 abstract "The central role of actylcholine (Ach) in the transmission of the nerve impulse has been accepted ever since the pioneering experiments of (). In 1953, Nachmansohn postulated that in electrically excitable membranes, the attachment of Ach to a protein, the Ach receptor (AchR), induced a change in membrane cation permeability. He also recognized that the functions of the AchR, as well as of the enzyme responsible for the synthesis of Ach, choline acetyltransferase (ChA, EC 2.3.1.6), and the enzyme responsible for the hydrolysis of Ach (acetylcholinesterase), form a coordinated, cyclic process. The flow of cations triggered by the attachment of Ach to the AchR is passive, whereas Ach is a highenergy compound. Metabolic energy is required to restore ion gradients to the state existing before the transient Ach-induced permeability change, and metabolic energy is required for the synthesis of Ach. Thus, ChA is a key link between the functions of the Ach cycle and the metabolism of the cell." @default.
- W4238052140 created "2022-05-12" @default.
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- W4238052140 date "2003-11-14" @default.
- W4238052140 modified "2023-10-03" @default.
- W4238052140 title "Choline Acetyltransferase" @default.
- W4238052140 doi "https://doi.org/10.1385/0-89603-079-2:273" @default.
- W4238052140 hasPublicationYear "2003" @default.
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