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- W4238072313 abstract "Bovine lactoferrin (bLf) reduces Staphylococcus aureus infection in premature infants and promotes the growth of Bifidobacterium infantis, a predominant infant gut species. We hypothesized bLf in combination with B. infantis would reduce the severity of systemic S. aureus infection. To determine the effects of oral administration of bLf and B. infantis on the course of systemic S. aureus infection. Colostrum-deprived piglets consumed formulas containing 4g/l whey (CON) or bLf (LF). Half were gavaged with B. infantis (109 CFU/d) resulting in two additional groups (BI or COMB). On d7, piglets were intravenously injected with S. aureus. Blood samples were collected pre-infection and every 12h post-infection for immune analyses. Tissue samples were collected on d12 for analysis of bacterial abundance and gene expression. Pre-infection, LF piglets had lower serum IL-10, higher % lymphocytes and lower % neutrophils than BI or COMB. After infection, dietary bLf increased piglet weight gain, reduced staphylococcal counts in kidney and tended to lower staphylococcal counts in lung and heart. Dietary bLf also decreased kidney IL-10 and increased lung IFNγ mRNA. B. infantis increased splenic IFNγ expression. Renal toll-like receptor 2 was upregulated in BI piglets, but not in COMB piglets. Post-infection, BI piglets had increased serum IL-10 and decreased memory T cell populations. LF and COMB piglets had fewer circulating monocytes and B-cells than CON or BI piglets. Dietary bLf and B. infantis produced independent and tissue-specific effects. Piglets fed bLf alone or in combination with B. infantis mounted a more effective immune response and exhibited lower bacterial abundance, whereas B. infantis administration was associated with greater tissue bacterial abundance. This study provides biological underpinnings to the clinical benefits of bLf observed in preterm infants, but does not support B. infantis administration during S. aureus infection." @default.
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- W4238072313 date "2018-04-01" @default.
- W4238072313 modified "2023-10-02" @default.
- W4238072313 title "Dietary Bovine Lactoferrin Reduces Staphylococcus aureus in the Tissues and Modulates the Immune Response in Piglets Systemically Infected with Staphylococcus aureus" @default.
- W4238072313 doi "https://doi.org/10.3945/cdn.117.001982" @default.
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