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- W4238172899 abstract "Objective: To determine the role of macrophage MAP Kinase Phosphatase-5 (MKP-5) in the pathogenesis of atherosclerosis. Approach and Results: Lethally irradiated LDLR -/- mice were transplanted with wild-type (WT) or MKP-5 deficient (MKP-5 -/- ) bone marrow and subjected to high-fat feeding. Mice transplanted with MKP-5 -/- bone marrow developed smaller atherosclerotic lesions accompanied by decreased lipid deposition and macrophage content compared to WT. Lack of MKP-5 in macrophages led to decreased plasma levels of interleukin-1α (IL-1α) and IL-7, elevated anti-inflammatory cytokines IL-1 receptor antagonist (IL-1rn) and IL-4. Mechanistically, lack of MKP-5 in macrophages inhibited ox-LDL-induced foam cell formation through enhanced cholesterol efflux mediated by increased expression of ATP-binding cassette transporters ABCA1 and ABCG1. Conclusions: These data suggest that the macrophage MKP-5 deficiency reduces atherosclerosis progression and foam cell formation through amelioration of cholesterol efflux and inhibition of inflammation." @default.
- W4238172899 created "2022-05-12" @default.
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- W4238172899 date "2017-05-01" @default.
- W4238172899 modified "2023-09-28" @default.
- W4238172899 title "Abstract 433: Map Kinase Phosphatase-5 Deficiency in Macrophages Protects Against Atherogenesis" @default.
- W4238172899 doi "https://doi.org/10.1161/atvb.37.suppl_1.433" @default.
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