Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238175058> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4238175058 endingPage "295" @default.
- W4238175058 startingPage "286" @default.
- W4238175058 abstract "Introduction e binding of the antitumor drug cisplatin and other platinum group metal complexes, especially ruthenium(II), rhodium(III), iridium(III), platinum(II), and palladium(II) to amino acids, nucleosides, nucleotides, and particularly to DNA is still an interesting subject and has given considerable impetus to research in the area of metal ion interactions with nucleic acid constituents. Ruthenium complexes are an order of magnitude less toxic than cisplatin, and aqua complexes if used directly will be less toxic as some hydrolyzed side products are responsible for toxicity. From a literature survey [1-3], it is revealed that many potential alternative metallopharmaceuticals have been developed, ruthenium being one of the most promising, and are currently undergoing clinical trials [4-7]. Another point of interest is that DNA is not the only target. Binding to proteins, RNA [8-10] and several sulphur donor ligands, present in the blood, are available for kinetic and thermodynamic competition [11, 12]." @default.
- W4238175058 created "2022-05-12" @default.
- W4238175058 date "2011-04-15" @default.
- W4238175058 modified "2023-09-26" @default.
- W4238175058 title "Kinetic and Mechanistic Studies on the Reaction of DL-Methionine with [(H2O)(tap)2RuORu(tap)2(H2O)]2+ in Aqueous Medium at Physiological pH" @default.
- W4238175058 cites W2056628406 @default.
- W4238175058 doi "https://doi.org/10.1201/b12873-17" @default.
- W4238175058 hasPublicationYear "2011" @default.
- W4238175058 type Work @default.
- W4238175058 citedByCount "0" @default.
- W4238175058 crossrefType "book-chapter" @default.
- W4238175058 hasConcept C17538187 @default.
- W4238175058 hasConcept C178790620 @default.
- W4238175058 hasConcept C184651966 @default.
- W4238175058 hasConcept C185592680 @default.
- W4238175058 hasConcept C21951064 @default.
- W4238175058 hasConcept C2780912031 @default.
- W4238175058 hasConcept C2993699647 @default.
- W4238175058 hasConcept C39432304 @default.
- W4238175058 hasConcept C515207424 @default.
- W4238175058 hasConcept C55493867 @default.
- W4238175058 hasConcept C87717796 @default.
- W4238175058 hasConceptScore W4238175058C17538187 @default.
- W4238175058 hasConceptScore W4238175058C178790620 @default.
- W4238175058 hasConceptScore W4238175058C184651966 @default.
- W4238175058 hasConceptScore W4238175058C185592680 @default.
- W4238175058 hasConceptScore W4238175058C21951064 @default.
- W4238175058 hasConceptScore W4238175058C2780912031 @default.
- W4238175058 hasConceptScore W4238175058C2993699647 @default.
- W4238175058 hasConceptScore W4238175058C39432304 @default.
- W4238175058 hasConceptScore W4238175058C515207424 @default.
- W4238175058 hasConceptScore W4238175058C55493867 @default.
- W4238175058 hasConceptScore W4238175058C87717796 @default.
- W4238175058 hasLocation W42381750581 @default.
- W4238175058 hasOpenAccess W4238175058 @default.
- W4238175058 hasPrimaryLocation W42381750581 @default.
- W4238175058 hasRelatedWork W1983441613 @default.
- W4238175058 hasRelatedWork W2005486536 @default.
- W4238175058 hasRelatedWork W2011388732 @default.
- W4238175058 hasRelatedWork W2039981107 @default.
- W4238175058 hasRelatedWork W2048274302 @default.
- W4238175058 hasRelatedWork W2069074470 @default.
- W4238175058 hasRelatedWork W2089163773 @default.
- W4238175058 hasRelatedWork W2362170731 @default.
- W4238175058 hasRelatedWork W4294585351 @default.
- W4238175058 hasRelatedWork W2184003409 @default.
- W4238175058 isParatext "false" @default.
- W4238175058 isRetracted "false" @default.
- W4238175058 workType "book-chapter" @default.