Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238202386> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4238202386 endingPage "102" @default.
- W4238202386 startingPage "96" @default.
- W4238202386 abstract "Factors associated with prolongation of the prothrombin time were analyzed in 94 patients with intra-abdominal sepsis. Patients were randomized prospectively to receive either the combination of tobramycin and clindamycin (TM/C) or moxalactam (MOX). This paper presents a retrospective review designed to compare the frequency of prolonged clotting times and to analyze predisposing factors. Prothrombin time (PT) prolongation occurred more frequently in patients given moxalactam (19 of 47 patients) than in patients given the combination of tobramycin and clindamycin (9 of 47 patients) (p < 0.05). Prolongation of the partial thromboplastin time (PTT) occurred in all patients with a prolonged PT. Liver disease, upper gastrointestinal surgery, and use of cimetidine were more frequent in those patients with abnormal PT/PTT values (p < 0.05). Two moxalactam-treated patients with subsequent PT/ PTT prolongation had individual clotting factors assayed before moxalactam treatment and at the time of detection of the abnormal PT. The activity of clotting factors II, VII, VIII, IX, X, and XII was reduced during MOX therapy. Treatment with vitamin K reversed the abnormality. In view of underlying abnormalities and rapid response to parenteral vitamin K, the mechanism is probably an acute vitamin K deficiency superimposed upon chronic vitamin K deficiency. In patients with intraabdominal infection, those treated with MOX are more likely to develop abnormal PT than those treated with TM/C. Since abnormal PT/PTT was common even in TM/C patients, supplemental vitamin K should be considered for all seriously ill, older patients with abdominal infections." @default.
- W4238202386 created "2022-05-12" @default.
- W4238202386 creator A5020679230 @default.
- W4238202386 creator A5044077450 @default.
- W4238202386 creator A5049206298 @default.
- W4238202386 creator A5050331083 @default.
- W4238202386 creator A5056267366 @default.
- W4238202386 creator A5089726507 @default.
- W4238202386 date "1985-01-01" @default.
- W4238202386 modified "2023-09-26" @default.
- W4238202386 title "Clinical Risk Factors for Prolonged PT/PTT in Abdominal Sepsis Patients Treated with Moxalactam or Tobramycin Plus Clindamycin" @default.
- W4238202386 doi "https://doi.org/10.1097/00000658-198520110-00014" @default.
- W4238202386 hasPublicationYear "1985" @default.
- W4238202386 type Work @default.
- W4238202386 citedByCount "0" @default.
- W4238202386 crossrefType "journal-article" @default.
- W4238202386 hasAuthorship W4238202386A5020679230 @default.
- W4238202386 hasAuthorship W4238202386A5044077450 @default.
- W4238202386 hasAuthorship W4238202386A5049206298 @default.
- W4238202386 hasAuthorship W4238202386A5050331083 @default.
- W4238202386 hasAuthorship W4238202386A5056267366 @default.
- W4238202386 hasAuthorship W4238202386A5089726507 @default.
- W4238202386 hasConcept C126322002 @default.
- W4238202386 hasConcept C141071460 @default.
- W4238202386 hasConcept C2775832221 @default.
- W4238202386 hasConcept C2777458120 @default.
- W4238202386 hasConcept C2778384902 @default.
- W4238202386 hasConcept C2778974779 @default.
- W4238202386 hasConcept C2780434524 @default.
- W4238202386 hasConcept C2909971615 @default.
- W4238202386 hasConcept C501593827 @default.
- W4238202386 hasConcept C64778159 @default.
- W4238202386 hasConcept C71924100 @default.
- W4238202386 hasConcept C86803240 @default.
- W4238202386 hasConcept C89423630 @default.
- W4238202386 hasConcept C90924648 @default.
- W4238202386 hasConceptScore W4238202386C126322002 @default.
- W4238202386 hasConceptScore W4238202386C141071460 @default.
- W4238202386 hasConceptScore W4238202386C2775832221 @default.
- W4238202386 hasConceptScore W4238202386C2777458120 @default.
- W4238202386 hasConceptScore W4238202386C2778384902 @default.
- W4238202386 hasConceptScore W4238202386C2778974779 @default.
- W4238202386 hasConceptScore W4238202386C2780434524 @default.
- W4238202386 hasConceptScore W4238202386C2909971615 @default.
- W4238202386 hasConceptScore W4238202386C501593827 @default.
- W4238202386 hasConceptScore W4238202386C64778159 @default.
- W4238202386 hasConceptScore W4238202386C71924100 @default.
- W4238202386 hasConceptScore W4238202386C86803240 @default.
- W4238202386 hasConceptScore W4238202386C89423630 @default.
- W4238202386 hasConceptScore W4238202386C90924648 @default.
- W4238202386 hasIssue "1" @default.
- W4238202386 hasLocation W42382023861 @default.
- W4238202386 hasOpenAccess W4238202386 @default.
- W4238202386 hasPrimaryLocation W42382023861 @default.
- W4238202386 hasRelatedWork W2009089640 @default.
- W4238202386 hasRelatedWork W2011473088 @default.
- W4238202386 hasRelatedWork W2012126084 @default.
- W4238202386 hasRelatedWork W2043595362 @default.
- W4238202386 hasRelatedWork W2085225490 @default.
- W4238202386 hasRelatedWork W2330805188 @default.
- W4238202386 hasRelatedWork W2394265553 @default.
- W4238202386 hasRelatedWork W2414365193 @default.
- W4238202386 hasRelatedWork W2416999678 @default.
- W4238202386 hasRelatedWork W4238202386 @default.
- W4238202386 hasVolume "201" @default.
- W4238202386 isParatext "false" @default.
- W4238202386 isRetracted "false" @default.
- W4238202386 workType "article" @default.