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- W4238217396 abstract "Risk assessment is the process of determining chemical tolerance limits in the environment and can be defined as Z Hazards x L Exposures. Hazard can be factored into two responses to a chemical: cellular damage by the chemical and repair/protection by the host. The Mixed Function Oxidase system is very responsive to xenobiotics and may reflect hazard. A recent electrophilic SE2 mechanism suggested that this was the result of a relationship between the oxidation potential of the induced MFO active site and the C-H bond strength of xenobiotic. This study tested and supported this model of enthalpic biochemical control, demonstrating that an induced active site has the potential to metabolize any C-H bond that is weaker than the C-H bond strength of its inducer. Chlorinated chemicals exhibited a stronger oxidation potential than predicted, presenting a risk of uncontrolled oxidations that may initiate chemical disease." @default.
- W4238217396 created "2022-05-12" @default.
- W4238217396 creator A5054670471 @default.
- W4238217396 date "2018-10-04" @default.
- W4238217396 modified "2023-10-17" @default.
- W4238217396 title "Chemical control of the mixed function oxidase system and its implications in determining biological hazard" @default.
- W4238217396 doi "https://doi.org/10.22215/etd/1990-12403" @default.
- W4238217396 hasPublicationYear "2018" @default.
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