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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238222281> ?p ?o ?g. }

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• W4238222281 abstract "Abstract ATAD2 is a cancer‐associated protein whose bromodomain has been described as among the least druggable of that target class. Starting from a potent lead, permeability and selectivity were improved through a dual approach: 1) using CF 2 as a sulfone bio‐isostere to exploit the unique properties of fluorine, and 2) using 1,3‐interactions to control the conformation of a piperidine ring. This resulted in the first reported low‐nanomolar, selective and cell permeable chemical probe for ATAD2." @default.
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• W4238222281 date "2016-08-17" @default.
• W4238222281 modified "2023-09-27" @default.
• W4238222281 title "A Chemical Probe for the ATAD2 Bromodomain" @default.
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• W4238222281 doi "https://doi.org/10.1002/ange.201603928" @default.
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