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- W4238228511 abstract "<p>In this work, we developed the first 3D PEEK based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis. 3D printed PEEK/graphene nanocomposite scaffold was deposited with drug laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under NIR laser irradiation. The bioactive hydroxyapatite coating significantly boosted the stem cell proliferation <i>in vitro</i> and promoted the new bone growth <i>in vivo</i>. The presence of antibiotics and anti-cancer drugs enabled eradication of drug resistant bacteria as well as ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by the on-demand laser induced heating. The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair as well as multimodal treatment of osteosarcoma and osteomyelitis.</p>" @default.
- W4238228511 created "2022-05-12" @default.
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- W4238228511 date "2021-06-09" @default.
- W4238228511 modified "2023-09-27" @default.
- W4238228511 title "3D Printed Multifunctional PEEK Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis" @default.
- W4238228511 doi "https://doi.org/10.26434/chemrxiv.14679750" @default.
- W4238228511 hasPublicationYear "2021" @default.
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