Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238288077> ?p ?o ?g. }
- W4238288077 abstract "Background In many countries, second‐generation ('atypical') antipsychotic drugs have become the first‐line drug treatment for people with schizophrenia. It is not clear how the effects of the various second‐generation antipsychotic drugs differ. Objectives To evaluate the effects of quetiapine compared with other second‐generation (atypical) antipsychotic drugs in the treatment of people with schizophrenia and schizophrenia‐like psychoses. Search methods We searched the Cochrane Schizophrenia Group Trials Register (May 2010), inspected references of all identified studies, and contacted relevant pharmaceutical companies, drug approval agencies and authors of trials for additional information. Selection criteria We included all randomised controlled trials (RCTs) comparing oral quetiapine with other oral forms of atypical antipsychotic medication in people with schizophrenia or schizophrenia‐like psychoses. Data collection and analysis We extracted data independently. For dichotomous data, we calculated risk ratios (RRs) and their 95% confidence intervals (CIs) on an intention‐to‐treat basis based on a random‐effects model. We calculated number needed to treat for an additional beneficial outcome (NNTB) where appropriate. For continuous data, we calculated mean differences (MDs), again based on a random‐effects model. Main results Efficacy data tended to favour the control drugs over quetiapine (Positive and Negative Syndrome Scale (PANSS) total score vs olanzapine: 11 RCTs, n = 1486, mean quetiapine endpoint score 3.67 higher, CI 1.95 to 5.39, low quality; vs risperidone: 13 RCTs, n = 2155, mean quetiapine endpoint score 1.74 higher, CI 0.19 to 3.29, moderate quality; vs paliperidone: 1 RCT, n = 319, mean quetiapine endpoint score 6.30 higher, CI 2.77 to 9.83, moderate quality), but the clinical meaning of these data is unclear. No clear mental state differences were noted when quetiapine was compared with clozapine, aripiprazole or ziprasidone. Compared with olanzapine, quetiapine produced slightly fewer movement disorders (7 RCTs, n = 1127, RR use of antiparkinson medication 0.51, CI 0.32 to 0.81, moderate quality) and less weight gain (8 RCTs, n = 1667, RR 0.68, CI 0.51 to 0.92, moderate quality) and glucose elevation, but increased QTc prolongation (3 RCTs, n = 643, MD 4.81, CI 0.34 to 9.28). Compared with risperidone, quetiapine induced slightly fewer movement disorders (8 RCTs, n = 2163, RR use of antiparkinson medication 0.5, CI 0.36 to 0.69, moderate quality), less prolactin increase (7 RCTs, n = 1733, MD ‐35.25, CI ‐43.59 to ‐26.91) and some related adverse effects but greater cholesterol increase (6 RCTs, n = 1473, MD 8.57, CI 4.85 to 12.29). On the basis of limited data, compared with paliperidone, quetiapine induced fewer parkinsonian side effects (1 RCT, n = 319, RR use of antiparkinson medication 0.64, CI 0.45 to 0.91, moderate quality) and less prolactin increase (1 RCT, n = 319, MD ‐49.30, CI ‐57.80 to ‐40.80) and weight gain (1 RCT, n = 319, RR weight gain of 7% or more of total body weight 2.52, CI 0.5 to 12.78, moderate quality). Compared with ziprasidone, quetiapine induced slightly fewer extrapyramidal adverse effects (1 RCT, n = 522, RR use of antiparkinson medication 0.43, CI 0.2 to 0.93, moderate quality) and less prolactin increase. On the other hand, quetiapine was more sedating and led to greater weight gain (2 RCTs, n = 754, RR 2.22, CI 1.35 to 3.63, moderate quality) and cholesterol increase when compared with ziprasidone. Authors' conclusions Available evidence from trials suggests that most people who start quetiapine stop taking it within a few weeks (around 60%). Comparisons with amisulpride, sertindole and zotepine do not exist. Although efficacy data favour olanzapine and risperidone compared with quetiapine, the clinical meaning of these data remains unclear. Quetiapine may produce fewer parkinsonian effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine. Quetiapine appears to have a similar weight gain profile to risperidone, as well as clozapine and aripiprazole (although data are very limited for the latter two comparators). Quetiapine may produce greater weight gain than ziprasidone and less weight gain than olanzapine and paliperidone. Most data that have been reported within existing comparisons are of very limited value because of assumptions and biases within them. Much scope is available for further research into the effects of this widely used drug." @default.
- W4238288077 created "2022-05-12" @default.
- W4238288077 creator A5002251483 @default.
- W4238288077 creator A5009198511 @default.
- W4238288077 creator A5016537819 @default.
- W4238288077 creator A5032091622 @default.
- W4238288077 creator A5042937393 @default.
- W4238288077 creator A5046445175 @default.
- W4238288077 date "2013-11-18" @default.
- W4238288077 modified "2023-09-26" @default.
- W4238288077 title "Quetiapine versus other atypical antipsychotics for schizophrenia" @default.
- W4238288077 cites W102941371 @default.
- W4238288077 cites W1591259115 @default.
- W4238288077 cites W1598602811 @default.
- W4238288077 cites W1858285960 @default.
- W4238288077 cites W1904924604 @default.
- W4238288077 cites W1911611356 @default.
- W4238288077 cites W1964162160 @default.
- W4238288077 cites W1966702092 @default.
- W4238288077 cites W1970800124 @default.
- W4238288077 cites W1974217915 @default.
- W4238288077 cites W1976692274 @default.
- W4238288077 cites W1977185679 @default.
- W4238288077 cites W1977779499 @default.
- W4238288077 cites W1978040764 @default.
- W4238288077 cites W1980853407 @default.
- W4238288077 cites W1985065973 @default.
- W4238288077 cites W1987702754 @default.
- W4238288077 cites W1988482389 @default.
- W4238288077 cites W1990084913 @default.
- W4238288077 cites W1990190466 @default.
- W4238288077 cites W1992857340 @default.
- W4238288077 cites W1998036667 @default.
- W4238288077 cites W1998796817 @default.
- W4238288077 cites W1999425626 @default.
- W4238288077 cites W1999689270 @default.
- W4238288077 cites W2000767861 @default.
- W4238288077 cites W2002288542 @default.
- W4238288077 cites W2002442062 @default.
- W4238288077 cites W2007980588 @default.
- W4238288077 cites W2008291750 @default.
- W4238288077 cites W2008463165 @default.
- W4238288077 cites W200959462 @default.
- W4238288077 cites W2012504287 @default.
- W4238288077 cites W2014036031 @default.
- W4238288077 cites W2016801434 @default.
- W4238288077 cites W2018613434 @default.
- W4238288077 cites W2020844317 @default.
- W4238288077 cites W2021799665 @default.
- W4238288077 cites W2023839473 @default.
- W4238288077 cites W2024355407 @default.
- W4238288077 cites W2025918713 @default.
- W4238288077 cites W2026673513 @default.
- W4238288077 cites W2029663626 @default.
- W4238288077 cites W2030580618 @default.
- W4238288077 cites W2031474706 @default.
- W4238288077 cites W2032712358 @default.
- W4238288077 cites W2033431868 @default.
- W4238288077 cites W2035157527 @default.
- W4238288077 cites W2036966602 @default.
- W4238288077 cites W2042051086 @default.
- W4238288077 cites W2043320066 @default.
- W4238288077 cites W2048516268 @default.
- W4238288077 cites W2055256747 @default.
- W4238288077 cites W2058874144 @default.
- W4238288077 cites W2059444637 @default.
- W4238288077 cites W2060473560 @default.
- W4238288077 cites W2063504947 @default.
- W4238288077 cites W2068192942 @default.
- W4238288077 cites W2074785386 @default.
- W4238288077 cites W2074916419 @default.
- W4238288077 cites W2075153233 @default.
- W4238288077 cites W2076484723 @default.
- W4238288077 cites W2077001392 @default.
- W4238288077 cites W2080468819 @default.
- W4238288077 cites W2081921819 @default.
- W4238288077 cites W2081978467 @default.
- W4238288077 cites W2083252023 @default.
- W4238288077 cites W2083507801 @default.
- W4238288077 cites W2085184923 @default.
- W4238288077 cites W2085360366 @default.
- W4238288077 cites W2087161442 @default.
- W4238288077 cites W2088408644 @default.
- W4238288077 cites W2089642450 @default.
- W4238288077 cites W2091847338 @default.
- W4238288077 cites W2096402187 @default.
- W4238288077 cites W2099467664 @default.
- W4238288077 cites W2099704493 @default.
- W4238288077 cites W2102868524 @default.
- W4238288077 cites W2107325590 @default.
- W4238288077 cites W2109196233 @default.
- W4238288077 cites W2112167247 @default.
- W4238288077 cites W2115139068 @default.
- W4238288077 cites W2119866172 @default.
- W4238288077 cites W2120647667 @default.
- W4238288077 cites W2125435699 @default.
- W4238288077 cites W2128659393 @default.
- W4238288077 cites W2130235475 @default.
- W4238288077 cites W2135029321 @default.
- W4238288077 cites W2136389525 @default.