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• W4238290392 abstract "Traumatic brain injury (TBI) resulting from blast exposure (Wolf, 2009; Triton Report, 2011) affects an estimated 12–23% of the 2.4 million U.S. military servicemen and women deployed to Iraq and Afghanistan (Hoge, 2009; Terrio, 2009a). Blast-related TBI is a significant risk factor for persistent neuropsychiatric and cognitive impairment (Hoge, 2008a,b; Tanielian, 2008; Benzinger, 2009; Ling, 2009; Terrio, 2009a; Vasterling, 2009; Brenner, 2010; Hicks, 2010; MacDonald, 2011; Peskind, 2011). Our research team is uncovering evidence linking repetitive concussive TBI with later development of chronic traumatic encephalopathy (CTE), a devastating tau protein-linked chronic neurodegenerative disease (McKee, 2009; McKee, 2010; McKee, 2012). Blast mouse model, immunohistochemistry, Western blotting, electrophysiology, neurobehavior. We report the first case series of postmortem brains from U.S. military veterans with histories of blast exposure and/or concussive injury. Examination of these military veteran brains revealed evidence of CTE neuropathology that was indistinguishable from the pathology in a comparison group of postmortem brains obtained from the youngest athletes with CTE studied to date. In the same study, we demonstrated that C57BL/6 mice exposed to a single blast also develop CTE-linked tau neuropathology, axonopathy, microvasculopathy, and neurodegeneration. Moreover, blast-exposed mice also developed persistent learning and memory deficits that correlated with impaired axonal conduction and defective long-term synaptic plasticity. The neuropathology and neurobehavioral deficits we observed in blast-exposed mice closely recapitulate key clinical features observed in individuals affected by CTE (Baugh, 2012). Finally, we demonstrated that head immobilization during blast exposure blocked blast-induced neurobehavioral impairments, a finding that points to traumatic head acceleration as a major pathogenic contributor to blast-related CTE. Our data identify common determinants leading to CTE neuropathology in blast-exposed military veterans and head-injured athletes, and additionally, provide mechanistic evidence linking blast exposure to later development of CTE-linked neuropathology and neurobehavioral deficits." @default.
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• W4238290392 date "2013-07-01" @default.
• W4238290392 modified "2023-09-27" @default.
• W4238290392 title "P3-037: Modeling and elucidating the pathobiology of blast-induced traumatic brain injury in the mouse" @default.
• W4238290392 doi "https://doi.org/10.1016/j.jalz.2013.05.1106" @default.
• W4238290392 hasPublicationYear "2013" @default.
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