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- W4238292359 abstract "Trans, trans-muconic acid (tt-MA) is one of the most important metabolites of benzene, a pollutant ubiquitously distributed in ambient air and classified in 1982 as a group I carcinogen. For its sensitivity and specificity, tt-MA excreted in urine is considered a good biological marker of benzene exposure. In this study, seminal tt-MA levels in occupationally nonexposed subjects (n = 32) have been determined. The seminal fluid of normozoospermic subjects contained an average tt-MA concentration (170 ± 100 ng ml−1) significantly lower than that of teratozoospermic (310 ± 180 ng ml−1; P<0.01), oligozoospermic (400 ± 180 ng ml−1; P<0.001), and oligoasthenozoospermic (430 ± 230 ng ml−1; P<0.01) subjects. A negative correlation existed between tt-MA levels and sperm concentration (r= — 0.62; P<0.001), percentage of normal spermatozoa (r= — 0.41; P<0.05), and percentage of vital spermatozoa (r= — 0.89; P<0.001). Average tt-MA levels detected in seminal plasma were higher in smokers (350 ± 160 ng ml−1) than in nonsmokers (280 ± 210 ng ml−1). These results show that seminal plasma tt-MA content could be an important biological indicator for evaluating the negative effects of benzene on spermatogenesis." @default.
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- W4238292359 date "2001-09-01" @default.
- W4238292359 modified "2023-10-14" @default.
- W4238292359 title "Assessment of trans, trans-muconic acid in human seminal plasma" @default.
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- W4238292359 doi "https://doi.org/10.1111/j.1439-0272.2001.tb01500.x" @default.
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