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• W4238300309 abstract "The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs. Recent studies demonstrate the general application of siRNAs to silence gene expression in a range of cell types and in whole mammals. Beyond their value for dissecting gene functions and target validation, siRNAs also hold great potential as gene-specific therapeutic agents." @default.
• W4238300309 created "2022-05-12" @default.
• W4238300309 creator A5006395020 @default.
• W4238300309 date "2004-01-01" @default.
• W4238300309 modified "2023-10-18" @default.
• W4238300309 title "Therapeutic siRNAs" @default.
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• W4238300309 doi "https://doi.org/10.1016/j.tips.2003.11.006" @default.
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