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- W4238307537 endingPage "112" @default.
- W4238307537 startingPage "101" @default.
- W4238307537 abstract "Abstract Autism spectrum disorder (ASD) is a heretogenous developmental disorder characterized by deficits in sociability and communication and by repetitive and/or restrictive behaviors. Currently, only comorbid manifestations can be alleviated (such as seizures and sleep disturbance) not core behavioral symptoms. Recent studies have increasingly implicated mitochondrial dysfunction as a cause of ASD. Mitochondria play an integral role in many cellular functions and are susceptible to many pathophysiological insults. Derangements in mitochondrial structure and function provide a scientific rationale for experimental therapeutics. Meanwhile, the high-fat, low-carbohydrate ketogenic diet (KD) has been shown to enhance mitochondrial function through a multiplicity of mechanisms. Reviewed herein is clinical and basic laboratory evidence for the use of metabolism-based therapies such as the KD in the treatment of ASD, as well as emerging comorbid models of epilepsy and autism. Future research directions aimed at validating such therapeutic approaches and identifying novel mechanistic targets are discussed." @default.
- W4238307537 created "2022-05-12" @default.
- W4238307537 creator A5010085174 @default.
- W4238307537 creator A5018391871 @default.
- W4238307537 creator A5084554132 @default.
- W4238307537 date "2016-10-01" @default.
- W4238307537 modified "2023-09-24" @default.
- W4238307537 title "Metabolic Therapy for Autism Spectrum Disorder and Comorbidities" @default.
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