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- W4238326197 abstract "Treatment modalities for cancer involve physical manipulations, such as surgery, immunology, radiation, chemotherapy or gene editing. This is a proposal for an information–based modality. This modality does not change the internal state of the cancer cell directly — instead, the cancer cell is manipulated by giving it information to instruct the cell to perform an action. This modality is based on a theory of Structure Encoding in DNA where information about body part structure controls the epigenetic state of cells in the process of development from pluripotent cells to fully differentiated cells. This implies a model of cancer where cells stuck in an epigenetic state during the process of differentiation lead to malignancy, called the Epigenetic Differentiation Model. A major feature of the Structure Encoding Theory is that the characteristics of the differentiated cell are affected by intercellular information passed in the tissue microenvironment, which specifies the exact location of a cell in a body part structure. This is done by exosomes that carry fragments of long non–coding RNA and transposons that convey structure information. In the normal process of epigenetic differentiation, the information passed may lead to apoptosis due to the constraints of a particular body part structure. The proposed treatment involves determining what structure information is being passed in a particular tumor, then adding artificial exosomes that overwhelm the current information with commands for the cells to go into apoptosis." @default.
- W4238326197 created "2022-05-12" @default.
- W4238326197 creator A5028930424 @default.
- W4238326197 date "2020-07-21" @default.
- W4238326197 modified "2023-09-23" @default.
- W4238326197 title "A Proposed Information-based Modality for the Treatment of Cancer" @default.
- W4238326197 doi "https://doi.org/10.31219/osf.io/wdba6" @default.
- W4238326197 hasPublicationYear "2020" @default.
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