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- W4238331475 abstract "We studied the effects of intraplantar morphine in the formalin test in mice. Intraplantarly administered morphine (30-300 μg) induced analgesic effects at lower doses than intraperitoneally administered morphine. Following the administration of [3H]morphine, the % of radioactivity present in brain was the same by either route. In contrast, higher radioactivity values appeared in the injected paw in those mice intraplantarly injected. Since local morphine induces analgesia at doses lower than the intraperitoneally administered drug, especially in the second phase of the test, and the access to brain is undistinguishable, we propose that local morphine enhances central opiate analgesia in the formalin test in mice." @default.
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- W4238331475 date "2000-01-01" @default.
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- W4238331475 title "Effects of Intraplantar Morphine in the Mouse Formalin Test" @default.
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- W4238331475 doi "https://doi.org/10.1016/s0021-5198(19)30611-0" @default.
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