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- W4238339715 abstract "Atherosclerosis is defined as a focal, inflammatory and fibro-proliferative response to endothelial injury. The development of atheromatous lesions in the coronary tree is predominantly an asymptomatic process that may remain quiescent without any clinical manifestations. The unpredictable and acute nature of cardiovascular anomalies makes diagnosis and treatment of this disease an outstanding medical challenge. Thus, a need exists for non-invasive techniques that facilitate mechanical measurements at the microscopic level which then can be directly correlated to biomarker localization within lesion sites. To characterize these sites in vitro, we used time-resolved scanning acoustic microscopy (TRSAM). This technique allows for non-invasive interrogation of tissue samples with optical resolution at the micrometer scale. Furthermore, we combined TRSAM with micro-Raman spectroscopy (mRS) to investigate plaque morphology with regard to specific biomarkers. In our preliminary results we characterized mechanoelastic and biochemical regions containing high cholesterol, phosphate and carbonate apatite that are typically present in atherosclerotic lesions. The mechanoelastic evaluation of these regions was determined using TRSAM. We found that calcified lesions, for example, exhibit ultrasonic velocities of 1810 m/s ± 25 m/s and are more rigid and stiffer than normal blood vessel tissues." @default.
- W4238339715 created "2022-05-12" @default.
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- W4238339715 date "2013-01-01" @default.
- W4238339715 modified "2023-10-12" @default.
- W4238339715 title "Ultrasonic biomicroscopy and micro-Raman spectroscopy for the mechanochemical characterization of atheromatous lesions" @default.
- W4238339715 doi "https://doi.org/10.1121/1.4800372" @default.
- W4238339715 hasPublicationYear "2013" @default.
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