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- W4238341716 endingPage "8940" @default.
- W4238341716 startingPage "8921" @default.
- W4238341716 abstract "The thioetherification of heteroaryl chlorides is an essential synthetic methodology that provides access to bioactive drugs and agrochemicals. Due to their (actual or potential) industrial importance, the development of efficient and low-temperature protocols for accessing these compounds is a requirement for economic and ecologic reasons. A particular highly effective catalytic protocol using the Pd/PTABS system at only 50 °C was developed accordingly. The coupling between chloroheteroarenes and a variety of less reactive arylthiols and alkylthiols was carried out with a high efficiency. Heteroarenes of commercial relevance such as purines and pyrimidines were also found to be useful substrates for the reported transformation. The commercial drug Imuran (azathioprine) was synthesized as an example, and its preparation could be optimized. DFT studies were performed to understand the electronic effects of the tested ligands on the catalytic reaction." @default.
- W4238341716 created "2022-05-12" @default.
- W4238341716 creator A5015378980 @default.
- W4238341716 creator A5018292962 @default.
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- W4238341716 creator A5046495404 @default.
- W4238341716 creator A5054674963 @default.
- W4238341716 creator A5056810506 @default.
- W4238341716 creator A5077424846 @default.
- W4238341716 date "2019-06-10" @default.
- W4238341716 modified "2023-10-18" @default.
- W4238341716 title "Pd/PTABS: Low-Temperature Thioetherification of Chloro(hetero)arenes" @default.
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