FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238362568> ?p ?o ?g. }

• W4238362568 endingPage "1194" @default.
• W4238362568 startingPage "1194" @default.
• W4238362568 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Cell-free DNA (cfDNA) sequencing has emerged as an effective laboratory method for rapid and noninvasive diagnosis in prenatal screening testing, organ transplant rejection screening, and oncology liquid biopsies but clinical experience for use of this technology in diagnostic evaluation of infections in immunocompromised hosts is limited. </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> We conducted an exploratory study using next-generation sequencing (NGS) for detection of microbial cfDNA in a cohort of ten immunocompromised patients with febrile neutropenia, pneumonia or intra-abdominal infection. </ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Pathogen identification by cfDNA NGS demonstrated positive agreement with conventional diagnostic laboratory methods in 7 (70%) cases, including patients with proven/probable invasive aspergillosis, <ns4:italic>Pneumocystis jirovecii</ns4:italic> pneumonia, <ns4:italic>Stenotrophomonas maltophilia</ns4:italic> bacteremia, Cytomegalovirus and Adenovirus viremia. NGS results were discordant in 3 (30%) cases including two patients with culture negative sepsis who had undergone hematopoietic stem cell transplant in whom cfDNA testing identified the etiological agent of sepsis; and one kidney transplant recipient with invasive aspergillosis who had received >6 months of antifungal therapy prior to NGS testing.</ns4:p><ns4:p> <ns4:bold>Conclusion:</ns4:bold> These observations support the clinical utility of measurement of microbial cfDNA sequencing from peripheral blood for rapid noninvasive diagnosis of infections in immunocompromised hosts. Larger studies are needed.</ns4:p>" @default.
• W4238362568 created "2022-05-12" @default.
• W4238362568 creator A5013495583 @default.
• W4238362568 creator A5022910363 @default.
• W4238362568 creator A5028200056 @default.
• W4238362568 creator A5041410897 @default.
• W4238362568 creator A5041943790 @default.
• W4238362568 creator A5044052521 @default.
• W4238362568 creator A5057832944 @default.
• W4238362568 creator A5072362033 @default.
• W4238362568 creator A5075051705 @default.
• W4238362568 creator A5090627780 @default.
• W4238362568 date "2019-11-21" @default.
• W4238362568 modified "2023-10-11" @default.
• W4238362568 title "Next-generation sequencing of microbial cell-free DNA for rapid noninvasive diagnosis of infectious diseases in immunocompromised hosts" @default.
• W4238362568 cites W1963957045 @default.
• W4238362568 cites W1966475133 @default.
• W4238362568 cites W1977474566 @default.
• W4238362568 cites W1984856718 @default.
• W4238362568 cites W1989337302 @default.
• W4238362568 cites W2039458277 @default.
• W4238362568 cites W2054723603 @default.
• W4238362568 cites W2113002556 @default.
• W4238362568 cites W2119962983 @default.
• W4238362568 cites W2123859227 @default.
• W4238362568 cites W2137575148 @default.
• W4238362568 cites W2142261360 @default.
• W4238362568 cites W2166628353 @default.
• W4238362568 cites W2202734965 @default.
• W4238362568 cites W2467961197 @default.
• W4238362568 cites W2587873513 @default.
• W4238362568 cites W2592945756 @default.
• W4238362568 cites W2608919594 @default.
• W4238362568 cites W2752220092 @default.
• W4238362568 cites W2766599816 @default.
• W4238362568 cites W2766745670 @default.
• W4238362568 cites W2770354963 @default.
• W4238362568 cites W2809930572 @default.
• W4238362568 cites W2884501029 @default.
• W4238362568 cites W2898830086 @default.
• W4238362568 cites W2899457010 @default.
• W4238362568 cites W2901531873 @default.
• W4238362568 cites W2901765816 @default.
• W4238362568 cites W2902789910 @default.
• W4238362568 cites W2911798461 @default.
• W4238362568 cites W2913376703 @default.
• W4238362568 cites W2930465847 @default.
• W4238362568 cites W2950076417 @default.
• W4238362568 doi "https://doi.org/10.12688/f1000research.19766.3" @default.
• W4238362568 hasPublicationYear "2019" @default.
• W4238362568 type Work @default.
• W4238362568 citedByCount "29" @default.
• W4238362568 countsByYear W42383625682020 @default.
• W4238362568 countsByYear W42383625682021 @default.
• W4238362568 countsByYear W42383625682022 @default.
• W4238362568 countsByYear W42383625682023 @default.
• W4238362568 crossrefType "journal-article" @default.
• W4238362568 hasAuthorship W4238362568A5013495583 @default.
• W4238362568 hasAuthorship W4238362568A5022910363 @default.
• W4238362568 hasAuthorship W4238362568A5028200056 @default.
• W4238362568 hasAuthorship W4238362568A5041410897 @default.
• W4238362568 hasAuthorship W4238362568A5041943790 @default.
• W4238362568 hasAuthorship W4238362568A5044052521 @default.
• W4238362568 hasAuthorship W4238362568A5057832944 @default.
• W4238362568 hasAuthorship W4238362568A5072362033 @default.
• W4238362568 hasAuthorship W4238362568A5075051705 @default.
• W4238362568 hasAuthorship W4238362568A5090627780 @default.
• W4238362568 hasBestOaLocation W42383625681 @default.
• W4238362568 hasConcept C126322002 @default.
• W4238362568 hasConcept C203014093 @default.
• W4238362568 hasConcept C2777914695 @default.
• W4238362568 hasConcept C2779443120 @default.
• W4238362568 hasConcept C501593827 @default.
• W4238362568 hasConcept C71924100 @default.
• W4238362568 hasConcept C86803240 @default.
• W4238362568 hasConcept C89423630 @default.
• W4238362568 hasConceptScore W4238362568C126322002 @default.
• W4238362568 hasConceptScore W4238362568C203014093 @default.
• W4238362568 hasConceptScore W4238362568C2777914695 @default.
• W4238362568 hasConceptScore W4238362568C2779443120 @default.
• W4238362568 hasConceptScore W4238362568C501593827 @default.
• W4238362568 hasConceptScore W4238362568C71924100 @default.
• W4238362568 hasConceptScore W4238362568C86803240 @default.
• W4238362568 hasConceptScore W4238362568C89423630 @default.
• W4238362568 hasLocation W42383625681 @default.
• W4238362568 hasLocation W42383625682 @default.
• W4238362568 hasOpenAccess W4238362568 @default.
• W4238362568 hasPrimaryLocation W42383625681 @default.
• W4238362568 hasRelatedWork W1641042124 @default.
• W4238362568 hasRelatedWork W1990804418 @default.
• W4238362568 hasRelatedWork W1993764875 @default.
• W4238362568 hasRelatedWork W2013243191 @default.
• W4238362568 hasRelatedWork W2082860237 @default.
• W4238362568 hasRelatedWork W2130076355 @default.
• W4238362568 hasRelatedWork W2188071822 @default.
• W4238362568 hasRelatedWork W3081723200 @default.
• W4238362568 hasRelatedWork W3146197192 @default.
• W4238362568 hasRelatedWork W3194328422 @default.

• next