Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238374985> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4238374985 abstract "Abstract Background: Pregnancies occur during HIV-1 vaccine clinical trials, despite requirements for women of reproductive potential to use effective contraception. Deployment of an effective HIV-1 vaccine regimen will likely target adolescents and young adults and therefore safety for pregnant and breastfeeding women will need to be addressed. Methods: We performed a retrospective, cross-protocol analysis to identify and compare pregnancy outcomes reported in 53 Phase 1 and Phase 2a HIV-1 vaccine clinical trials conducted by the HIV Vaccine Trials Network (HVTN). Results: 2673 women of reproductive potential were identified and 193 pregnancies were reported. 39 of 53 (74%) studies had at least one pregnancy reported with an overall pregnancy rate of 3.15 per 100 woman-years (w-yr). While active contraception use was required during study participation, 13 of the 53 studies also contained a long-term follow up period during which pregnancy was no longer discouraged. The pregnancy rate during main study participation was 3.09 per 100 w-yr, while pregnancies occurred at a slightly greater rate in the long-term follow up period (3.22 per 100 w-yr). Adverse pregnancy outcomes were reported at similar rates between vaccinees and placebo recipients when vaccine vectors, adjuvant used, or geographic region were examined. Conclusion: Although there is considerable heterogeneity amongst the different vaccine trials, there appears to be no obvious indication of increased risk of adverse pregnancy or birth outcomes in these early phase HIV-1 vaccine studies. More complete data on pregnancy outcomes should be collected in a systematic fashion in early phase HIV-1 vaccine clinical trials to better inform subsequent efficacy trials." @default.
- W4238374985 created "2022-05-12" @default.
- W4238374985 creator A5017596396 @default.
- W4238374985 creator A5024875100 @default.
- W4238374985 creator A5039731482 @default.
- W4238374985 creator A5057518319 @default.
- W4238374985 creator A5064259175 @default.
- W4238374985 creator A5074003622 @default.
- W4238374985 date "2020-04-30" @default.
- W4238374985 modified "2023-10-02" @default.
- W4238374985 title "A retrospective analysis of incident pregnancy in Phase 1 and 2a HIV-1 vaccine study participants does not support concern for adverse pregnancy or birth outcomes" @default.
- W4238374985 doi "https://doi.org/10.21203/rs.3.rs-23939/v1" @default.
- W4238374985 hasPublicationYear "2020" @default.
- W4238374985 type Work @default.
- W4238374985 citedByCount "0" @default.
- W4238374985 crossrefType "posted-content" @default.
- W4238374985 hasAuthorship W4238374985A5017596396 @default.
- W4238374985 hasAuthorship W4238374985A5024875100 @default.
- W4238374985 hasAuthorship W4238374985A5039731482 @default.
- W4238374985 hasAuthorship W4238374985A5057518319 @default.
- W4238374985 hasAuthorship W4238374985A5064259175 @default.
- W4238374985 hasAuthorship W4238374985A5074003622 @default.
- W4238374985 hasBestOaLocation W42383749851 @default.
- W4238374985 hasConcept C126322002 @default.
- W4238374985 hasConcept C131872663 @default.
- W4238374985 hasConcept C187212893 @default.
- W4238374985 hasConcept C197934379 @default.
- W4238374985 hasConcept C2776283161 @default.
- W4238374985 hasConcept C2779234561 @default.
- W4238374985 hasConcept C2781413609 @default.
- W4238374985 hasConcept C535046627 @default.
- W4238374985 hasConcept C54355233 @default.
- W4238374985 hasConcept C71924100 @default.
- W4238374985 hasConcept C86803240 @default.
- W4238374985 hasConceptScore W4238374985C126322002 @default.
- W4238374985 hasConceptScore W4238374985C131872663 @default.
- W4238374985 hasConceptScore W4238374985C187212893 @default.
- W4238374985 hasConceptScore W4238374985C197934379 @default.
- W4238374985 hasConceptScore W4238374985C2776283161 @default.
- W4238374985 hasConceptScore W4238374985C2779234561 @default.
- W4238374985 hasConceptScore W4238374985C2781413609 @default.
- W4238374985 hasConceptScore W4238374985C535046627 @default.
- W4238374985 hasConceptScore W4238374985C54355233 @default.
- W4238374985 hasConceptScore W4238374985C71924100 @default.
- W4238374985 hasConceptScore W4238374985C86803240 @default.
- W4238374985 hasLocation W42383749851 @default.
- W4238374985 hasLocation W42383749852 @default.
- W4238374985 hasOpenAccess W4238374985 @default.
- W4238374985 hasPrimaryLocation W42383749851 @default.
- W4238374985 hasRelatedWork W10104907 @default.
- W4238374985 hasRelatedWork W12069763 @default.
- W4238374985 hasRelatedWork W16334032 @default.
- W4238374985 hasRelatedWork W1887433 @default.
- W4238374985 hasRelatedWork W20049668 @default.
- W4238374985 hasRelatedWork W20853652 @default.
- W4238374985 hasRelatedWork W2803110 @default.
- W4238374985 hasRelatedWork W5324923 @default.
- W4238374985 hasRelatedWork W807275 @default.
- W4238374985 hasRelatedWork W9274382 @default.
- W4238374985 isParatext "false" @default.
- W4238374985 isRetracted "false" @default.
- W4238374985 workType "article" @default.