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- W4238422083 abstract "This chapter discusses the placebo-controlled and observational studies of lithium. The molecular effects of lithium have been reviewed. Its direct targets include inositol monophosphatase, inositol polyphosphate 1-phosphatase, biophosphate nucleotidase, fructose 1, 6-biophosphatase, phosphogluco-mutase, and glycogen synthase kinase-3. These enzymes are largely phosphomonoesterases, which are magnesium-dependent. Lithium also has effects on adenylate cyclase, arachidonic acid, and myristoylated alanine-rich C kinase substrate. The role of lamotrigine in the treatment of bipolar disorder has been reviewed, and combination therapy with lamotrigine plus other mood stabilizers, including lithium, has been particularly elaborated. The diagnosis of bipolar affective disorder, including the bipolar spectrum, co-morbidity of bipolar disorder, issues of bipolar disorder in children and adolescence, and the pathophysiology of bipolar disorder have been reviewed in relation to neuroimaging studies. It is suggested that topiramate reduced renal lithium excretion through several mechanisms, possibly as a carbonic anhydrase inhibitor coupled with sodium depletion." @default.
- W4238422083 created "2022-05-12" @default.
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- W4238422083 date "2007-01-01" @default.
- W4238422083 modified "2023-09-27" @default.
- W4238422083 title "3 Lithium" @default.
- W4238422083 doi "https://doi.org/10.1016/s0378-6080(06)29003-2" @default.
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