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- W4238451972 abstract "Abstract Haemolytic uraemic syndrome (HUS) is a thrombotic microangiopathy characterized by the triad of thrombocytopenia, microangiopathic haemolytic anaemia, and acute kidney injury. It is most often caused by Shiga toxin-producing Escherichia coli (STEC-HUS), and any HUS not caused by this is often termed atypical HUS (aHUS). aHUS may be caused by an underlying complement system abnormality (primary aHUS) or by a range of precipitating events, such as infections or drugs (secondary aHUS). Management of STEC-HUS is supportive. In aHUS, plasma exchange is the initial treatment of choice until ADAMTS13 activity is available to exclude thrombotic thrombocytopenic purpura as a diagnosis. Once this has been done, eculizumab should be instigated as soon as possible." @default.
- W4238451972 created "2022-05-12" @default.
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- W4238451972 date "2020-03-01" @default.
- W4238451972 modified "2023-09-26" @default.
- W4238451972 title "Haemolytic uraemic syndrome" @default.
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- W4238451972 doi "https://doi.org/10.1093/med/9780198746690.003.0496" @default.
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