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- W4238474906 abstract "Liver–intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade ( P =0.015), lymphatic invasion ( P =0.033), lymph node metastasis ( P =0.015), and an advanced pTNM stage ( P =0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy." @default.
- W4238474906 created "2022-05-12" @default.
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- W4238474906 date "2004-05-01" @default.
- W4238474906 modified "2023-09-25" @default.
- W4238474906 title "Reduced expression of liver?intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma" @default.
- W4238474906 doi "https://doi.org/10.1016/s0304-3835(04)00226-5" @default.
- W4238474906 hasPublicationYear "2004" @default.
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