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- W4238484587 abstract "Thyroid hormones are key regulators of metabolism. In adipose tissue, changes in thyroid status result in alterations of lipolytic capacity. The effects of these hormones are mediated by thyroid hormone receptors that modulate gene transcription. Very few target genes have been identified in adipose tissue. To investigate the effect of T3 on gene expression in human adipocytes, primary cultures of human sc adipose tissue explants were treated with T3. 32P-labeled cDNA probes prepared from isolated adipocyte total RNA were hybridized to cDNA arrays representing 1,176 genes. Among the statistically significant variations in mRNA levels with more than 1.3-fold difference, 13 and 6 genes were positively and negatively regulated, respectively (n = 3). The genes encoded proteins that were involved in signal transduction, lipid metabolism, apoptosis, and inflammatory response. Using RT-competitive PCR, we showed a down-regulation of phosphodiesterase 3B, α2A-adrenergic receptor, and G protein αi2 subunit mRNAs, and an up-regulation of β2-adrenergic receptor mRNA. These regulations may explain the T3-mediated increase in catecholamine-induced lipolysis. The down-regulation of sterol regulatory element binding protein-1c, a transcription factor controlling lipogenic gene expression, may constitute a link between thyrotoxicosis and insulin resistance. Thus, these data suggest that T3 modulates expression of genes with a wide range of function in human adipose tissue." @default.
- W4238484587 created "2022-05-12" @default.
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- W4238484587 date "2002-02-01" @default.
- W4238484587 modified "2023-10-18" @default.
- W4238484587 title "Regulation of Human Adipocyte Gene Expression by Thyroid Hormone" @default.
- W4238484587 doi "https://doi.org/10.1210/jc.87.2.630" @default.
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