FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238505877> ?p ?o ?g. }

• W4238505877 endingPage "78" @default.
• W4238505877 startingPage "65" @default.
• W4238505877 abstract "The present experiments were designed to further examine the hypothesis that receptor subtype determines the direction of dopamine's (DA) ability to modulate neostriatal neuronal responses. We have reported that DA potntiates responses medited by activation of N-methyl-d-aspartate (NMDA) receptors, but attenuates responses mediated by activation of non-NMDA rceptors in neocortex [Cepeda et al. (1992b) Synapse, 11:330]. and neostriatum [Cepeda et al. (1993) Proc. Natl. Acad. Sci. U.S.A., 90:9576–9580]. In thse studies, rsponses to excitatory amined whetere this differential modulpation also applies to components of synaptic responses evoked by electrical Stimulation of Neostriatal afferents and mediated by activation of specific subtypes of EAA receptors. Using brain slices, the actions of DA and its receptor specific agonistss on components of neostriatal synaptic responses that were mediated either by NMDA or non-NMDA rceptors were assessed. Responses mediatd by NMDA recepotors were potentiated by DA while those mediated by non-NMDA receptors were attenuated. These findings provide further support for the htpothesis that the direction of modulatory action of DA is determindd bt the spcific subtype of EAA rdeptor activted. In addition, the enhancement of NMDA rceptor-mediated responses was mimicked bty application of SKF 38393, D1 receptor agonist. Quinpirole, a D2 redceptor agonist, consistently attenuated responses mediated by activation of non-NMDA receptors. Thus, the complex modultory actions of DA are dependent upon combinations of co-activation kof specific subtypes of EAA and DA receptors. These findings are of clijnical relecance since the actions of DA and EAAs khave been implicated in neurological and affective disorder. © 1996 Wiley-Liss, Inc." @default.
• W4238505877 created "2022-05-12" @default.
• W4238505877 creator A5019691586 @default.
• W4238505877 creator A5038508116 @default.
• W4238505877 creator A5045747018 @default.
• W4238505877 creator A5049120573 @default.
• W4238505877 creator A5058974801 @default.
• W4238505877 date "1996-09-01" @default.
• W4238505877 modified "2023-09-30" @default.
• W4238505877 title "Neuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slices" @default.
• W4238505877 cites W1008413412 @default.
• W4238505877 cites W1486039058 @default.
• W4238505877 cites W1595473599 @default.
• W4238505877 cites W1625996387 @default.
• W4238505877 cites W1718056607 @default.
• W4238505877 cites W1880252216 @default.
• W4238505877 cites W1949767550 @default.
• W4238505877 cites W1958547196 @default.
• W4238505877 cites W1965176945 @default.
• W4238505877 cites W1967458028 @default.
• W4238505877 cites W1969940536 @default.
• W4238505877 cites W1970855023 @default.
• W4238505877 cites W1971692666 @default.
• W4238505877 cites W1972869078 @default.
• W4238505877 cites W1976782467 @default.
• W4238505877 cites W1979183785 @default.
• W4238505877 cites W1979532884 @default.
• W4238505877 cites W1980016842 @default.
• W4238505877 cites W1981910248 @default.
• W4238505877 cites W1982701589 @default.
• W4238505877 cites W1984770449 @default.
• W4238505877 cites W1985420205 @default.
• W4238505877 cites W1985760732 @default.
• W4238505877 cites W1987800172 @default.
• W4238505877 cites W1988041026 @default.
• W4238505877 cites W1989809574 @default.
• W4238505877 cites W1998229724 @default.
• W4238505877 cites W1999961963 @default.
• W4238505877 cites W2004094484 @default.
• W4238505877 cites W2007064958 @default.
• W4238505877 cites W2011532922 @default.
• W4238505877 cites W2012064273 @default.
• W4238505877 cites W2016464643 @default.
• W4238505877 cites W2020969390 @default.
• W4238505877 cites W2022233762 @default.
• W4238505877 cites W2023557680 @default.
• W4238505877 cites W2028183577 @default.
• W4238505877 cites W2035303728 @default.
• W4238505877 cites W2036152254 @default.
• W4238505877 cites W2036441989 @default.
• W4238505877 cites W2036739310 @default.
• W4238505877 cites W2039732315 @default.
• W4238505877 cites W2043187626 @default.
• W4238505877 cites W2044794793 @default.
• W4238505877 cites W2047172896 @default.
• W4238505877 cites W2051473177 @default.
• W4238505877 cites W2053159139 @default.
• W4238505877 cites W2054719361 @default.
• W4238505877 cites W2060697933 @default.
• W4238505877 cites W2062524799 @default.
• W4238505877 cites W2078472210 @default.
• W4238505877 cites W2079286566 @default.
• W4238505877 cites W2085798686 @default.
• W4238505877 cites W2087688448 @default.
• W4238505877 cites W2095951518 @default.
• W4238505877 cites W2147122909 @default.
• W4238505877 cites W2155599139 @default.
• W4238505877 cites W2160146829 @default.
• W4238505877 cites W2161197727 @default.
• W4238505877 cites W2164158899 @default.
• W4238505877 cites W2170042509 @default.
• W4238505877 cites W2395559438 @default.
• W4238505877 cites W2413513126 @default.
• W4238505877 cites W2463041108 @default.
• W4238505877 cites W3021526609 @default.
• W4238505877 cites W4238900569 @default.
• W4238505877 doi "https://doi.org/10.1002/syn.890240102" @default.
• W4238505877 hasPublicationYear "1996" @default.
• W4238505877 type Work @default.
• W4238505877 citedByCount "112" @default.
• W4238505877 countsByYear W42385058772012 @default.
• W4238505877 countsByYear W42385058772013 @default.
• W4238505877 countsByYear W42385058772014 @default.
• W4238505877 countsByYear W42385058772015 @default.
• W4238505877 countsByYear W42385058772016 @default.
• W4238505877 countsByYear W42385058772017 @default.
• W4238505877 countsByYear W42385058772018 @default.
• W4238505877 countsByYear W42385058772019 @default.
• W4238505877 countsByYear W42385058772020 @default.
• W4238505877 countsByYear W42385058772022 @default.
• W4238505877 crossrefType "journal-article" @default.
• W4238505877 hasAuthorship W4238505877A5019691586 @default.
• W4238505877 hasAuthorship W4238505877A5038508116 @default.
• W4238505877 hasAuthorship W4238505877A5045747018 @default.
• W4238505877 hasAuthorship W4238505877A5049120573 @default.
• W4238505877 hasAuthorship W4238505877A5058974801 @default.
• W4238505877 hasConcept C112592302 @default.
• W4238505877 hasConcept C120069818 @default.

• next