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- W4238512304 abstract "This chapter explores the role of microRNAs (miRNAs) in pituitary adenomas. miRNAs represent a class of small, 18- to 28-nucleotide-long, noncoding RNA molecules. Their major role is in the posttranscriptional regulation of protein expression, and their involvement was demonstrated in normal and in pathological cellular processes. In tumors, some miRNAs function as oncogenes, others as tumor suppressors; upregulation of oncogenic miRNAs (oncomiRs) has been demonstrated in cancer cells. Using the microarray technique, several deregulated miRNAs have been involved not only in pituitary cell proliferation and apoptosis but also in neoplastic transformation. Recent studies have demonstrated that several identified miRNAs are involved in cell proliferation, apoptosis, and corticotrophic tumorigenesis, suggesting that deregulation of miRNA expression may be involved in pituitary tumorigenesis. The results obtained from pituitary adenomas support the possibility that altered miRNA expression profiles might be involved in pituitary tumorigenesis. However, the lack of knowledge about miRNA target genes postpones full understanding of the biological functions of miRNAs. Predictive miRNAs could be potentially useful diagnostic markers, improving the classification of pituitary adenomas." @default.
- W4238512304 created "2022-05-12" @default.
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- W4238512304 date "2012-01-01" @default.
- W4238512304 modified "2023-09-26" @default.
- W4238512304 title "MicroRNAs" @default.
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- W4238512304 doi "https://doi.org/10.1016/b978-0-12-415830-6.00008-1" @default.
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