FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238528054> ?p ?o ?g. }

• W4238528054 endingPage "7556" @default.
• W4238528054 startingPage "7546" @default.
• W4238528054 abstract "Growth factors and cyclic AMP (cAMP) are known to activate distinct intracellular signaling pathways. Fibroblast growth factor (FGF) activates ras-dependent kinase cascades, resulting in the activation of MAP kinases, whereas cAMP activates protein kinase A. In this study, we report that growth factors and cAMP act synergistically to stimulate proenkephalin gene expression. Positive synergy between growth factor- and cAMP-activated signaling pathways on gene expression has not been previously reported, and we suggest that these synergistic interactions represent a useful model for analyzing interactions between these pathways. Transfection and mutational studies indicate that both FGF-dependent gene activation and cAMP-dependent gene activation require cAMP response element 2 (CRE-2), a previously characterized cAMP-dependent regulatory element. Furthermore, multiple copies of this element are sufficient to confer FGF regulation upon a minimal promoter, indicating that FGF and cAMP signaling converge upon transcription factors acting at CRE-2. Among many different ATF/AP-1 factors tested, two factors, ATF-3 and c-Jun, stimulate proenkephalin transcription in an FGF- or Ras-dependent fashion. Finally, we show that ATF-3 and c-Jun form heterodimeric complexes in SK-N-MC cells and that the levels of both proteins are increased in response to FGF but not cAMP. Together, these results indicate that growth factor- and cAMP-dependent signaling pathways converge at CRE-2 to synergistically stimulate gene expression and that ATF-3 and c-Jun regulate proenkephalin transcription in response to both growth factor- and cAMP-dependent intracellular signaling pathways." @default.
• W4238528054 created "2022-05-12" @default.
• W4238528054 creator A5001780861 @default.
• W4238528054 creator A5005910858 @default.
• W4238528054 creator A5020897587 @default.
• W4238528054 creator A5071643610 @default.
• W4238528054 creator A5076089901 @default.
• W4238528054 date "1994-11-01" @default.
• W4238528054 modified "2023-10-16" @default.
• W4238528054 title "Fibroblast Growth Factor and Cyclic AMP (cAMP) Synergistically Activate Gene Expression at a cAMP Response Element" @default.
• W4238528054 cites W1527816465 @default.
• W4238528054 cites W1529166175 @default.
• W4238528054 cites W1552975638 @default.
• W4238528054 cites W1726024662 @default.
• W4238528054 cites W1958327809 @default.
• W4238528054 cites W1977302628 @default.
• W4238528054 cites W1978798502 @default.
• W4238528054 cites W1988568219 @default.
• W4238528054 cites W1992472345 @default.
• W4238528054 cites W1993876642 @default.
• W4238528054 cites W1994975139 @default.
• W4238528054 cites W1996223704 @default.
• W4238528054 cites W1996409695 @default.
• W4238528054 cites W1997218197 @default.
• W4238528054 cites W1998279906 @default.
• W4238528054 cites W2000367276 @default.
• W4238528054 cites W2010295984 @default.
• W4238528054 cites W2015913211 @default.
• W4238528054 cites W2016386032 @default.
• W4238528054 cites W2020333978 @default.
• W4238528054 cites W2022125636 @default.
• W4238528054 cites W2023666553 @default.
• W4238528054 cites W2028158224 @default.
• W4238528054 cites W2028242823 @default.
• W4238528054 cites W2031588343 @default.
• W4238528054 cites W2039296938 @default.
• W4238528054 cites W2045876058 @default.
• W4238528054 cites W2047057752 @default.
• W4238528054 cites W2054100350 @default.
• W4238528054 cites W2063572593 @default.
• W4238528054 cites W2067388503 @default.
• W4238528054 cites W2067837253 @default.
• W4238528054 cites W2068446924 @default.
• W4238528054 cites W2069132844 @default.
• W4238528054 cites W2071833703 @default.
• W4238528054 cites W2072393635 @default.
• W4238528054 cites W2072606320 @default.
• W4238528054 cites W2073146277 @default.
• W4238528054 cites W2074651988 @default.
• W4238528054 cites W2076063939 @default.
• W4238528054 cites W2082797919 @default.
• W4238528054 cites W2096484165 @default.
• W4238528054 cites W2098553579 @default.
• W4238528054 cites W2108752163 @default.
• W4238528054 cites W2109399660 @default.
• W4238528054 cites W2115736681 @default.
• W4238528054 cites W2126440278 @default.
• W4238528054 cites W2133508418 @default.
• W4238528054 cites W2134939519 @default.
• W4238528054 cites W21386982 @default.
• W4238528054 cites W2172098581 @default.
• W4238528054 cites W2172323892 @default.
• W4238528054 cites W2178814694 @default.
• W4238528054 cites W2280111083 @default.
• W4238528054 cites W2416022039 @default.
• W4238528054 cites W4247855969 @default.
• W4238528054 doi "https://doi.org/10.1128/mcb.14.11.7546-7556.1994" @default.
• W4238528054 hasPublicationYear "1994" @default.
• W4238528054 type Work @default.
• W4238528054 citedByCount "0" @default.
• W4238528054 crossrefType "journal-article" @default.
• W4238528054 hasAuthorship W4238528054A5001780861 @default.
• W4238528054 hasAuthorship W4238528054A5005910858 @default.
• W4238528054 hasAuthorship W4238528054A5020897587 @default.
• W4238528054 hasAuthorship W4238528054A5071643610 @default.
• W4238528054 hasAuthorship W4238528054A5076089901 @default.
• W4238528054 hasConcept C101762097 @default.
• W4238528054 hasConcept C104317684 @default.
• W4238528054 hasConcept C132376346 @default.
• W4238528054 hasConcept C150194340 @default.
• W4238528054 hasConcept C153911025 @default.
• W4238528054 hasConcept C1629964 @default.
• W4238528054 hasConcept C165864922 @default.
• W4238528054 hasConcept C170493617 @default.
• W4238528054 hasConcept C184235292 @default.
• W4238528054 hasConcept C191709040 @default.
• W4238528054 hasConcept C199172495 @default.
• W4238528054 hasConcept C2910670019 @default.
• W4238528054 hasConcept C54355233 @default.
• W4238528054 hasConcept C62478195 @default.
• W4238528054 hasConcept C69053785 @default.
• W4238528054 hasConcept C74373430 @default.
• W4238528054 hasConcept C82867764 @default.
• W4238528054 hasConcept C86339819 @default.
• W4238528054 hasConcept C86803240 @default.
• W4238528054 hasConcept C95444343 @default.
• W4238528054 hasConcept C97029542 @default.
• W4238528054 hasConceptScore W4238528054C101762097 @default.

• next