Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238577716> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4238577716 endingPage "84" @default.
- W4238577716 startingPage "77" @default.
- W4238577716 abstract "Objective To localize genes conferring susceptibility to bipolar affective disorder. Methods Seven families were selected on the basis of containing multiple cases of bipolar affective disorder present in three or more generations, an absence of schizophrenia and unilineal transmission. DNA samples from these families were genotyped with 365 microsatellite markers spaced at approximately 10 cM intervals across the whole genome. All markers were subjected to initial two-point and three-point analyses using LOD score and model-free analysis. All regions producing a result significant atP<0.01 were then subjected to four-point LOD score analysis under the assumption of heterogeneity. Results A four-point LOD score of 2.8 was obtained using a dominant model and including unipolar cases as affected in the region of D12S342. Four-point LOD scores of 2 were obtained around D1S243, D1S251 and D3S1265. The positive results around D1S243 were accounted for by a LOD score of 3.1 occurring in a single pedigree. Conclusions Since there has been previous strong support for linkage to the region of 12q23-q24 around D12S342, it now seems very probable that it does indeed contain a gene influencing susceptibility to bipolar affective disorder. Some evidence for linkage in the region of 1q near to D1S251 has been reported in one previous study. It therefore seems that this region of 1q and the region of 1p close to D1S243 may also harbour susceptibility genes." @default.
- W4238577716 created "2022-05-12" @default.
- W4238577716 creator A5011307949 @default.
- W4238577716 creator A5013153231 @default.
- W4238577716 creator A5013242137 @default.
- W4238577716 creator A5037553646 @default.
- W4238577716 creator A5041313527 @default.
- W4238577716 creator A5043259963 @default.
- W4238577716 creator A5045240683 @default.
- W4238577716 creator A5055247456 @default.
- W4238577716 creator A5062243887 @default.
- W4238577716 creator A5063408005 @default.
- W4238577716 creator A5079162464 @default.
- W4238577716 date "2003-06-01" @default.
- W4238577716 modified "2023-09-27" @default.
- W4238577716 cites W120968873 @default.
- W4238577716 cites W1939097681 @default.
- W4238577716 cites W1974175508 @default.
- W4238577716 cites W1976741643 @default.
- W4238577716 cites W1984426003 @default.
- W4238577716 cites W1985066281 @default.
- W4238577716 cites W1997190651 @default.
- W4238577716 cites W2003702513 @default.
- W4238577716 cites W2009320570 @default.
- W4238577716 cites W2031554664 @default.
- W4238577716 cites W2046486132 @default.
- W4238577716 cites W2068725139 @default.
- W4238577716 cites W2070954442 @default.
- W4238577716 cites W2117703098 @default.
- W4238577716 cites W2123333307 @default.
- W4238577716 cites W2140573463 @default.
- W4238577716 cites W2170724596 @default.
- W4238577716 doi "https://doi.org/10.1097/00041444-200306000-00004" @default.
- W4238577716 hasPublicationYear "2003" @default.
- W4238577716 type Work @default.
- W4238577716 citedByCount "10" @default.
- W4238577716 countsByYear W42385777162015 @default.
- W4238577716 countsByYear W42385777162017 @default.
- W4238577716 crossrefType "journal-article" @default.
- W4238577716 hasAuthorship W4238577716A5011307949 @default.
- W4238577716 hasAuthorship W4238577716A5013153231 @default.
- W4238577716 hasAuthorship W4238577716A5013242137 @default.
- W4238577716 hasAuthorship W4238577716A5037553646 @default.
- W4238577716 hasAuthorship W4238577716A5041313527 @default.
- W4238577716 hasAuthorship W4238577716A5043259963 @default.
- W4238577716 hasAuthorship W4238577716A5045240683 @default.
- W4238577716 hasAuthorship W4238577716A5055247456 @default.
- W4238577716 hasAuthorship W4238577716A5062243887 @default.
- W4238577716 hasAuthorship W4238577716A5063408005 @default.
- W4238577716 hasAuthorship W4238577716A5079162464 @default.
- W4238577716 hasConcept C104317684 @default.
- W4238577716 hasConcept C118552586 @default.
- W4238577716 hasConcept C122735190 @default.
- W4238577716 hasConcept C169760540 @default.
- W4238577716 hasConcept C169900460 @default.
- W4238577716 hasConcept C180754005 @default.
- W4238577716 hasConcept C2776174506 @default.
- W4238577716 hasConcept C2776412080 @default.
- W4238577716 hasConcept C2993098900 @default.
- W4238577716 hasConcept C30481170 @default.
- W4238577716 hasConcept C31266012 @default.
- W4238577716 hasConcept C54355233 @default.
- W4238577716 hasConcept C61320498 @default.
- W4238577716 hasConcept C71924100 @default.
- W4238577716 hasConcept C86803240 @default.
- W4238577716 hasConceptScore W4238577716C104317684 @default.
- W4238577716 hasConceptScore W4238577716C118552586 @default.
- W4238577716 hasConceptScore W4238577716C122735190 @default.
- W4238577716 hasConceptScore W4238577716C169760540 @default.
- W4238577716 hasConceptScore W4238577716C169900460 @default.
- W4238577716 hasConceptScore W4238577716C180754005 @default.
- W4238577716 hasConceptScore W4238577716C2776174506 @default.
- W4238577716 hasConceptScore W4238577716C2776412080 @default.
- W4238577716 hasConceptScore W4238577716C2993098900 @default.
- W4238577716 hasConceptScore W4238577716C30481170 @default.
- W4238577716 hasConceptScore W4238577716C31266012 @default.
- W4238577716 hasConceptScore W4238577716C54355233 @default.
- W4238577716 hasConceptScore W4238577716C61320498 @default.
- W4238577716 hasConceptScore W4238577716C71924100 @default.
- W4238577716 hasConceptScore W4238577716C86803240 @default.
- W4238577716 hasIssue "2" @default.
- W4238577716 hasLocation W42385777161 @default.
- W4238577716 hasOpenAccess W4238577716 @default.
- W4238577716 hasPrimaryLocation W42385777161 @default.
- W4238577716 hasRelatedWork W1550810503 @default.
- W4238577716 hasRelatedWork W1573391922 @default.
- W4238577716 hasRelatedWork W1807662877 @default.
- W4238577716 hasRelatedWork W1999293393 @default.
- W4238577716 hasRelatedWork W2025798603 @default.
- W4238577716 hasRelatedWork W2095821536 @default.
- W4238577716 hasRelatedWork W2233797134 @default.
- W4238577716 hasRelatedWork W2995153489 @default.
- W4238577716 hasRelatedWork W4239401894 @default.
- W4238577716 hasRelatedWork W77030747 @default.
- W4238577716 hasVolume "13" @default.
- W4238577716 isParatext "false" @default.
- W4238577716 isRetracted "false" @default.
- W4238577716 workType "article" @default.