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- W4238590905 abstract "The critically ill patient presents the intensivist with the challenge of determining appro-priate and effective pharmacotherapy. The combination of hemodynamic compromise,organ dysfunction, fluid and electrolyte imbalances, and central nervous system (CNS)dysfunction may profoundly affect the efficacy and safety of commonly used drugs.Even slight changes in pharmacokinetics and pharmacodynamics can produce unexpectedresponses to pharmaceutical agents in the critically ill patient. Medications routinely usedoutside the intensive care unit (ICU) and considered to have a wide margin between thera-peutic and toxic effects may have a much narrower therapeutic window in the ICU. Somepharmacological effects may be seen with lower doses, while other pharmacologicaleffects may be blunted in the critically ill patient, despite the use of the recommendeddoses. Clearly, medication use in the ICU requires careful consideration before prescribingand subsequent close monitoring of the patient to achieve intended therapeutic effects andavoid potential risks. Another important consideration in the pursuit of optimal medicationuse in the ICU is the potential of drugs to interact with each other." @default.
- W4238590905 created "2022-05-12" @default.
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- W4238590905 date "2005-08-12" @default.
- W4238590905 modified "2023-09-25" @default.
- W4238590905 title "Disorders of Coagulation" @default.
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- W4238590905 doi "https://doi.org/10.1201/b14532-57" @default.
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