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- W4238599503 abstract "The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy--Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor. Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated." @default.
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- W4238599503 date "2000-12-01" @default.
- W4238599503 modified "2023-10-18" @default.
- W4238599503 title "Lipoatrophy Revisited" @default.
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- W4238599503 doi "https://doi.org/10.1016/s1043-2760(00)00309-x" @default.
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