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- W4238627706 abstract "Abstract Traditional photosensitizers (PSs) show reduced singlet oxygen ( 1 O 2 ) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non‐targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water‐dispersible membrane anchor (TBD‐anchor) PS with aggregation‐induced emission is designed and synthesized to generate 1 O 2 on the bacterial membrane. TBD‐anchor showed efficient antibacterial performance towards both Gram‐negative ( Escherichia coli ) and Gram‐positive bacteria ( Staphylococcus aureus ). Over 99.8 % killing efficiency was obtained for methicillin‐resistant S. aureus (MRSA) when they were exposed to 0.8 μ m of TBD‐anchor at a low white light dose (25 mW cm −2 ) for 10 minutes. TBD‐anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug‐resistant bacteria." @default.
- W4238627706 created "2022-05-12" @default.
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- W4238627706 date "2019-11-26" @default.
- W4238627706 modified "2023-10-14" @default.
- W4238627706 title "Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria" @default.
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- W4238627706 doi "https://doi.org/10.1002/ange.201907343" @default.
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