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- W4238660189 abstract "I have constructed a step-function binding theory for the reaction of Hg(II) and double-stranded polynucleotides. The theory specifies 2:1 base-Hg(II) complexes which bridge the double helix as the sites of the reaction when the ratio, r ≡ [Hg(II) added]/[base] ≦ 0.5. Several kinds of evidence indicate tthat Hg(II)-(thymidine)2 complexes are the most readily formed. Necessarily, the theory stipulaes perturbation of the Watson-Crick helix in reacting with Hg(II). The minimal perturbation is taken to be an axial chain shift by one base spacing. Combined with stoichiometric data on the complexing of Hg(II) and nucleosides, the chain-shift mechanism enables a quantitative evaluation of the average number of hydrogen ions released by a double-stranded polynucleotide in the interval r = 0 to r = 0.5. The theory largely explains the seeming anomaly in the mercurimetric pH-stat titration curve of highly ordered A–T polymer compared to natural DNAs. Since the chemical mechanism is the same for both A–T polymer and the natural DNAs, the reaction should prove useful in distinguishing between order and disorder in the base sequence of polynucleotides. I have also briefly discussed the application of the reaction to some aspects of the physical chemistry of polynucleotides and to the determination of their base composition and fractionation." @default.
- W4238660189 created "2022-05-12" @default.
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- W4238660189 date "1963-01-01" @default.
- W4238660189 modified "2023-09-27" @default.
- W4238660189 title "The reversible reaction of Hg (II) and double-stranded polynucleotides a step-function theory and its significance" @default.
- W4238660189 doi "https://doi.org/10.1016/0006-3002(63)90139-2" @default.
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