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- W4238672264 abstract "Isolated dissection of the mesenteric vessels is rare but increasingly recognized. This study aimed to evaluate patient characteristics, treatment patterns, and outcomes of mesenteric dissection using multi-institutional data. All patients at participant hospitals between January 2003 and December 2015 with dissection of the celiac artery (or its branches) or dissection of the superior mesenteric artery were included. Patients with an aortic dissection were excluded. Demographic, treatment, and follow-up data were collected. The primary outcomes included late vessel thrombosis (LVT) and aneurysmal degeneration. Twelve institutions identified 229 patients (220 with complete treatment records) with a mean age of 55 ± 12.5 years. Median time to last follow-up was 15 months (interquartile range, 3.8-32). Most patients were men (82% vs 18% women) and symptomatic at presentation (162 vs 65 asymptomatic). Isolated superior mesenteric artery dissection was more common than celiac artery dissection (n = 146 and 70, respectively). Concomitant dissection of both arteries was rare (n = 13). Primary treatment was medical in 146 patients with oral anticoagulation or antiplatelet therapy (n = 76 and 70, respectively), whereas 55 patients were observed. Six patients developed LVT and 22 patients aneurysmal degeneration (2.7% and 10%, respectively). For symptomatic patients without evidence of ischemia (n = 134), there was no difference in rate of LVT with medical therapy compared with observation alone (5 vs 0; P = .35). No asymptomatic patient (n = 64) had an episode of LVT at 5 years. Aneurysmal degeneration rates were 7.8% overall but did not differ among patients treated with medical therapy or observation alone (P = .82). Surgical or endovascular intervention was performed in 18 patients (3 ischemia, 13 pain, 1 aneurysmal degeneration, 1 asymptomatic). Excluding the patients treated for ischemia, there was no difference in LVT between patients treated by intervention and those treated medically (one vs five; P = .57). Isolated mesenteric dissection has a relatively benign course for most patients. Use of medical therapy did not improve outcomes over observation alone. Long-term follow-up is recommended because occasional patients develop aneurysmal degeneration or ischemia that may require repair." @default.
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- W4238672264 date "2016-08-01" @default.
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- W4238672264 title "Medical Therapy and Intervention Do Not Improve Uncomplicated Isolated Mesenteric Artery Dissection Outcomes Over Observation Alone" @default.
- W4238672264 doi "https://doi.org/10.1016/j.jvs.2016.05.016" @default.
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