Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238676886> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4238676886 abstract "Abstract Background In myelodysplastic syndromes (MDS), cytogenetic aberrations play an important role for classification and prognostication. However, more than 50% low risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for the detection of cytogenetic aberrations in MDS patients. Methods To characterize the subset of MDS with normal karyotype or failed chromosome banding analysis, we analyzed 144 patient samples with normal karyotype or undetectable through regular chromosome banding, which were subjected to parallel comparison via fluorescence in situ hybridization (FISH) and MLPA. Results MLPA identifies copy number changes in 16.7% of 144 MDS patients and we observed a significant difference in overall survival (OS) (median OS: undefined vs 27 months, p=0.0071) in patients with normal karyotype proved by MLPA, versus aberrant karyotype cohort as determined by MLPA. Interestingly, patients with undetectable karyotype via regular chromosome banding indicated inferior outcome. Conclusion Collectively, MDS patients with normal or undetectable karyotype via chromosome banding analysis can be further clarified by MLPA, providing more prognostic information that benefit for individualized therapy." @default.
- W4238676886 created "2022-05-12" @default.
- W4238676886 creator A5012193053 @default.
- W4238676886 creator A5018218343 @default.
- W4238676886 creator A5027893281 @default.
- W4238676886 creator A5048091307 @default.
- W4238676886 creator A5054274769 @default.
- W4238676886 creator A5054714447 @default.
- W4238676886 creator A5055420452 @default.
- W4238676886 creator A5057947122 @default.
- W4238676886 creator A5060155911 @default.
- W4238676886 creator A5071030446 @default.
- W4238676886 creator A5076464218 @default.
- W4238676886 creator A5077389488 @default.
- W4238676886 date "2020-08-17" @default.
- W4238676886 modified "2023-10-16" @default.
- W4238676886 title "Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients" @default.
- W4238676886 doi "https://doi.org/10.21203/rs.3.rs-32982/v1" @default.
- W4238676886 hasPublicationYear "2020" @default.
- W4238676886 type Work @default.
- W4238676886 citedByCount "0" @default.
- W4238676886 crossrefType "posted-content" @default.
- W4238676886 hasAuthorship W4238676886A5012193053 @default.
- W4238676886 hasAuthorship W4238676886A5018218343 @default.
- W4238676886 hasAuthorship W4238676886A5027893281 @default.
- W4238676886 hasAuthorship W4238676886A5048091307 @default.
- W4238676886 hasAuthorship W4238676886A5054274769 @default.
- W4238676886 hasAuthorship W4238676886A5054714447 @default.
- W4238676886 hasAuthorship W4238676886A5055420452 @default.
- W4238676886 hasAuthorship W4238676886A5057947122 @default.
- W4238676886 hasAuthorship W4238676886A5060155911 @default.
- W4238676886 hasAuthorship W4238676886A5071030446 @default.
- W4238676886 hasAuthorship W4238676886A5076464218 @default.
- W4238676886 hasAuthorship W4238676886A5077389488 @default.
- W4238676886 hasBestOaLocation W42386768861 @default.
- W4238676886 hasConcept C104317684 @default.
- W4238676886 hasConcept C120599132 @default.
- W4238676886 hasConcept C126322002 @default.
- W4238676886 hasConcept C143998085 @default.
- W4238676886 hasConcept C2777542201 @default.
- W4238676886 hasConcept C2781188995 @default.
- W4238676886 hasConcept C30481170 @default.
- W4238676886 hasConcept C36823959 @default.
- W4238676886 hasConcept C53226629 @default.
- W4238676886 hasConcept C54355233 @default.
- W4238676886 hasConcept C71924100 @default.
- W4238676886 hasConcept C86803240 @default.
- W4238676886 hasConceptScore W4238676886C104317684 @default.
- W4238676886 hasConceptScore W4238676886C120599132 @default.
- W4238676886 hasConceptScore W4238676886C126322002 @default.
- W4238676886 hasConceptScore W4238676886C143998085 @default.
- W4238676886 hasConceptScore W4238676886C2777542201 @default.
- W4238676886 hasConceptScore W4238676886C2781188995 @default.
- W4238676886 hasConceptScore W4238676886C30481170 @default.
- W4238676886 hasConceptScore W4238676886C36823959 @default.
- W4238676886 hasConceptScore W4238676886C53226629 @default.
- W4238676886 hasConceptScore W4238676886C54355233 @default.
- W4238676886 hasConceptScore W4238676886C71924100 @default.
- W4238676886 hasConceptScore W4238676886C86803240 @default.
- W4238676886 hasLocation W42386768861 @default.
- W4238676886 hasLocation W42386768862 @default.
- W4238676886 hasLocation W42386768863 @default.
- W4238676886 hasOpenAccess W4238676886 @default.
- W4238676886 hasPrimaryLocation W42386768861 @default.
- W4238676886 hasRelatedWork W11537943 @default.
- W4238676886 hasRelatedWork W11752745 @default.
- W4238676886 hasRelatedWork W16865729 @default.
- W4238676886 hasRelatedWork W19338733 @default.
- W4238676886 hasRelatedWork W24036813 @default.
- W4238676886 hasRelatedWork W25159765 @default.
- W4238676886 hasRelatedWork W25395577 @default.
- W4238676886 hasRelatedWork W25920950 @default.
- W4238676886 hasRelatedWork W27342008 @default.
- W4238676886 hasRelatedWork W773341 @default.
- W4238676886 isParatext "false" @default.
- W4238676886 isRetracted "false" @default.
- W4238676886 workType "article" @default.