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- W4238677276 abstract "Abstract Randomized controlled trials provide the gold standard for assessing the health benefits and risks of preventive treatments or interventions. Such trials typically need to be very large‐scale and long‐term. Hence, cost and logistic considerations imply that few such trials can be conducted, and there is a need for careful hypothesis development and preliminary testing, prior to the initiation of a full‐scale disease prevention trial. Aspects of the design, conduct monitoring and analysis of prevention trials are reviewed, along with a discussion of differences from therapeutic trials, and of the interplay with observational studies. The National Institutes of Health‐sponsored Women's Health Initiative, which includes both a multi‐faceted prevention trial, and a large cohort study, among postmenopausal women, provides an illustration of prevention trial considerations and trade‐offs." @default.
- W4238677276 created "2022-05-12" @default.
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- W4238677276 date "2005-02-15" @default.
- W4238677276 modified "2023-10-02" @default.
- W4238677276 title "Prevention Trials" @default.
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- W4238677276 doi "https://doi.org/10.1002/0470011815.b2a01047" @default.
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