Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238693622> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4238693622 abstract "Abstract Background: Mesenchymal stem cells (MSCs) are considered a promising tool for treating cerebral ischemic injury. However, their poor survival after transplantation limits their therapeutic effect and applications. Salidroside has been reported to exert potent cytoprotective and neuroprotective effects. This study aimed to investigate whether salidroside could improve MSC survival under hypoxic-ischemic conditions and, subsequently, alleviate cerebral ischemic injury in a rat model. Methods: MSCs were pretreated by salidroside under hypoxic-ischemic conditions. The cell proliferation, migratory capacity, and apoptosis were evaluated by means of Cell Counting Kit (CCK)-8, transwell assay, and flow cytometry. MSCs pretreated with salidroside were transplanted into the rats subsequent to middle cerebral artery occlusion. The grip strength, 2,3,5-triphenyltetrazolium chloride, and hematoxylin-eosin staining were used to analyze the therapeutic efficiency and pathological changes. The mature neuron marker NeuN and astrocyte marker GFAP in the focal area were detected by immunofluorescence. Results: These results indicated that salidroside promoted the proliferation, migration and reduced apoptosis of MSCs under hypoxic-ischemic conditions. In vivo experiments revealed that transplantation of salidroside-pretreated MSCs strengthened the therapeutic efficiency by enhancing neurogenesis and inhibiting neuroinflammation in the hippocampal CA1 area after ischemia. Conclusion: Our results suggest that pretreatment with salidroside could be an effective strategy to enhance the cell survival rate and the therapeutic effect of MSCs in treating cerebral ischemic injury." @default.
- W4238693622 created "2022-05-12" @default.
- W4238693622 creator A5002319716 @default.
- W4238693622 creator A5002718976 @default.
- W4238693622 creator A5010411934 @default.
- W4238693622 creator A5011735248 @default.
- W4238693622 creator A5013166048 @default.
- W4238693622 creator A5013360488 @default.
- W4238693622 creator A5014771081 @default.
- W4238693622 creator A5065074839 @default.
- W4238693622 creator A5081513542 @default.
- W4238693622 date "2020-08-18" @default.
- W4238693622 modified "2023-09-26" @default.
- W4238693622 title "Salidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo" @default.
- W4238693622 doi "https://doi.org/10.21203/rs.3.rs-59580/v1" @default.
- W4238693622 hasPublicationYear "2020" @default.
- W4238693622 type Work @default.
- W4238693622 citedByCount "0" @default.
- W4238693622 crossrefType "posted-content" @default.
- W4238693622 hasAuthorship W4238693622A5002319716 @default.
- W4238693622 hasAuthorship W4238693622A5002718976 @default.
- W4238693622 hasAuthorship W4238693622A5010411934 @default.
- W4238693622 hasAuthorship W4238693622A5011735248 @default.
- W4238693622 hasAuthorship W4238693622A5013166048 @default.
- W4238693622 hasAuthorship W4238693622A5013360488 @default.
- W4238693622 hasAuthorship W4238693622A5014771081 @default.
- W4238693622 hasAuthorship W4238693622A5065074839 @default.
- W4238693622 hasAuthorship W4238693622A5081513542 @default.
- W4238693622 hasBestOaLocation W42386936221 @default.
- W4238693622 hasConcept C126322002 @default.
- W4238693622 hasConcept C141071460 @default.
- W4238693622 hasConcept C142724271 @default.
- W4238693622 hasConcept C150903083 @default.
- W4238693622 hasConcept C185592680 @default.
- W4238693622 hasConcept C190283241 @default.
- W4238693622 hasConcept C198826908 @default.
- W4238693622 hasConcept C207001950 @default.
- W4238693622 hasConcept C25498285 @default.
- W4238693622 hasConcept C2777542381 @default.
- W4238693622 hasConcept C2779526882 @default.
- W4238693622 hasConcept C2911091166 @default.
- W4238693622 hasConcept C529278444 @default.
- W4238693622 hasConcept C541997718 @default.
- W4238693622 hasConcept C55493867 @default.
- W4238693622 hasConcept C71924100 @default.
- W4238693622 hasConcept C86803240 @default.
- W4238693622 hasConcept C98274493 @default.
- W4238693622 hasConceptScore W4238693622C126322002 @default.
- W4238693622 hasConceptScore W4238693622C141071460 @default.
- W4238693622 hasConceptScore W4238693622C142724271 @default.
- W4238693622 hasConceptScore W4238693622C150903083 @default.
- W4238693622 hasConceptScore W4238693622C185592680 @default.
- W4238693622 hasConceptScore W4238693622C190283241 @default.
- W4238693622 hasConceptScore W4238693622C198826908 @default.
- W4238693622 hasConceptScore W4238693622C207001950 @default.
- W4238693622 hasConceptScore W4238693622C25498285 @default.
- W4238693622 hasConceptScore W4238693622C2777542381 @default.
- W4238693622 hasConceptScore W4238693622C2779526882 @default.
- W4238693622 hasConceptScore W4238693622C2911091166 @default.
- W4238693622 hasConceptScore W4238693622C529278444 @default.
- W4238693622 hasConceptScore W4238693622C541997718 @default.
- W4238693622 hasConceptScore W4238693622C55493867 @default.
- W4238693622 hasConceptScore W4238693622C71924100 @default.
- W4238693622 hasConceptScore W4238693622C86803240 @default.
- W4238693622 hasConceptScore W4238693622C98274493 @default.
- W4238693622 hasLocation W42386936221 @default.
- W4238693622 hasOpenAccess W4238693622 @default.
- W4238693622 hasPrimaryLocation W42386936221 @default.
- W4238693622 hasRelatedWork W10178834 @default.
- W4238693622 hasRelatedWork W11583189 @default.
- W4238693622 hasRelatedWork W12495227 @default.
- W4238693622 hasRelatedWork W14142049 @default.
- W4238693622 hasRelatedWork W2797185 @default.
- W4238693622 hasRelatedWork W4617381 @default.
- W4238693622 hasRelatedWork W689303 @default.
- W4238693622 hasRelatedWork W12786530 @default.
- W4238693622 hasRelatedWork W15477601 @default.
- W4238693622 hasRelatedWork W16375900 @default.
- W4238693622 isParatext "false" @default.
- W4238693622 isRetracted "false" @default.
- W4238693622 workType "article" @default.