Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238703308> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4238703308 endingPage "91" @default.
- W4238703308 startingPage "86" @default.
- W4238703308 abstract "Recurrent respiratory papillomatosis (RRP) has a juvenile aggressive form and an adult more indolent form. Most cases of RRP are cytologically benign; however, some undergo malignant transformation. At present, there are no known markers that help identify patients at risk for aggressive disease. We investigated by immunohistochemistry expressions of topoisomerase alpha II, MIB-1, p53, p21, E-cadherin, retinoblastoma (RB) gene protein product, HER-2/neu, and steroid hormone receptors in a case of juvenile respiratory papillomatosis with malignant transformation to determine whether these markers are associated with malignant transformation. Histologic examination of the pulmonary lobectomy specimen revealed well-differentiated squamous carcinoma and invasive papillomatosis. Increased staining was found in areas of invasive papillomatosis for topoisomerase alpha II, p53, and MIB-1, with highest labeling indices in areas of squamous carcinoma. Staining intensity for RB gene protein product showed gradual decline from benign papilloma (3+) and invasive papillomatosis (2+) to squamous carcinoma (0–1+). Expression of p21 was similar in benign papilloma and invasive papillomatosis but showed reduction in squamous carcinoma. Expressions of E-cadherin, HER-2/neu, and steroid hormone receptors did not appear to correlate with biologic behavior. Increased topoisomerase alpha II and p53 expression along with reduced RB gene protein product and p21 expression may serve as markers of transformation to invasive papillomatosis and squamous carcinoma." @default.
- W4238703308 created "2022-05-12" @default.
- W4238703308 creator A5072814489 @default.
- W4238703308 creator A5073136575 @default.
- W4238703308 creator A5087998581 @default.
- W4238703308 date "2001-03-01" @default.
- W4238703308 modified "2023-10-18" @default.
- W4238703308 title "Topoisomerase Alpha II, Retinoblastoma Gene Product, and p53: Potential Relationships With Aggressive Behavior and Malignant Transformation in Recurrent Respiratory Papillomatosis" @default.
- W4238703308 cites W1911118961 @default.
- W4238703308 cites W1996690372 @default.
- W4238703308 cites W1997746557 @default.
- W4238703308 cites W2002025298 @default.
- W4238703308 cites W2007779260 @default.
- W4238703308 cites W2018073708 @default.
- W4238703308 cites W2021692622 @default.
- W4238703308 cites W2035160516 @default.
- W4238703308 cites W2046453762 @default.
- W4238703308 cites W2066123698 @default.
- W4238703308 cites W2095156669 @default.
- W4238703308 cites W2095911820 @default.
- W4238703308 cites W2097384171 @default.
- W4238703308 cites W2106038494 @default.
- W4238703308 cites W2137970297 @default.
- W4238703308 cites W2150097377 @default.
- W4238703308 cites W2157747407 @default.
- W4238703308 cites W2325609485 @default.
- W4238703308 cites W2336619833 @default.
- W4238703308 doi "https://doi.org/10.1097/00129039-200103000-00016" @default.
- W4238703308 hasPublicationYear "2001" @default.
- W4238703308 type Work @default.
- W4238703308 citedByCount "0" @default.
- W4238703308 crossrefType "journal-article" @default.
- W4238703308 hasAuthorship W4238703308A5072814489 @default.
- W4238703308 hasAuthorship W4238703308A5073136575 @default.
- W4238703308 hasAuthorship W4238703308A5087998581 @default.
- W4238703308 hasConcept C104317684 @default.
- W4238703308 hasConcept C142724271 @default.
- W4238703308 hasConcept C150194340 @default.
- W4238703308 hasConcept C195286587 @default.
- W4238703308 hasConcept C204232928 @default.
- W4238703308 hasConcept C2776350393 @default.
- W4238703308 hasConcept C2777063820 @default.
- W4238703308 hasConcept C2777546739 @default.
- W4238703308 hasConcept C2910019179 @default.
- W4238703308 hasConcept C2994491419 @default.
- W4238703308 hasConcept C31033888 @default.
- W4238703308 hasConcept C502942594 @default.
- W4238703308 hasConcept C55493867 @default.
- W4238703308 hasConcept C71924100 @default.
- W4238703308 hasConcept C86803240 @default.
- W4238703308 hasConceptScore W4238703308C104317684 @default.
- W4238703308 hasConceptScore W4238703308C142724271 @default.
- W4238703308 hasConceptScore W4238703308C150194340 @default.
- W4238703308 hasConceptScore W4238703308C195286587 @default.
- W4238703308 hasConceptScore W4238703308C204232928 @default.
- W4238703308 hasConceptScore W4238703308C2776350393 @default.
- W4238703308 hasConceptScore W4238703308C2777063820 @default.
- W4238703308 hasConceptScore W4238703308C2777546739 @default.
- W4238703308 hasConceptScore W4238703308C2910019179 @default.
- W4238703308 hasConceptScore W4238703308C2994491419 @default.
- W4238703308 hasConceptScore W4238703308C31033888 @default.
- W4238703308 hasConceptScore W4238703308C502942594 @default.
- W4238703308 hasConceptScore W4238703308C55493867 @default.
- W4238703308 hasConceptScore W4238703308C71924100 @default.
- W4238703308 hasConceptScore W4238703308C86803240 @default.
- W4238703308 hasIssue "1" @default.
- W4238703308 hasLocation W42387033081 @default.
- W4238703308 hasOpenAccess W4238703308 @default.
- W4238703308 hasPrimaryLocation W42387033081 @default.
- W4238703308 hasRelatedWork W2024245757 @default.
- W4238703308 hasRelatedWork W2026801002 @default.
- W4238703308 hasRelatedWork W2040367702 @default.
- W4238703308 hasRelatedWork W2061309010 @default.
- W4238703308 hasRelatedWork W2134751875 @default.
- W4238703308 hasRelatedWork W2331927344 @default.
- W4238703308 hasRelatedWork W2409899054 @default.
- W4238703308 hasRelatedWork W2884798626 @default.
- W4238703308 hasRelatedWork W4287186898 @default.
- W4238703308 hasRelatedWork W4206869974 @default.
- W4238703308 hasVolume "9" @default.
- W4238703308 isParatext "false" @default.
- W4238703308 isRetracted "false" @default.
- W4238703308 workType "article" @default.