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- W4238751017 abstract "We thank Zamora-Valdes and colleagues for their note of caution. We agree completely that our results can not be extrapolated to humans. Nevertheless, they open the discussion on new medical treatments of liver cirrhosis. There are probably species-specific differences with respect to the dose of atorvastatin. For our study, we used a dosage of 15 mg/kg/day. An even higher dosage of atorvastatin1-3 has been used in rat models in the field of cardiovascular research. It is correct that serum cholesterol levels may be high in patients with cholestasis, especially in patients with primary biliary cirrhosis. Interestingly, serum cholesterol levels did not increase after bile duct ligation in our model (Bile duct ligation = 63.8 ± 5.6 versus controls = 66.2 ± 4.2 mg/dL). We understand the concerns with respect to a cholesterol-lowering therapy in patients with cirrhosis, although the points raised in the correspondence may appear a bit far-fetched. Yet all these issues, among others, have to be considered in case of planning a study on the application of statins to influence the course of chronic liver disease in humans. Such studies on drugs that potentially may influence liver cirrhosis and/or portal hypertension are certainly warranted because our armamentarium is limited. Jonel Trebicka M.D.*, Tilman Sauerbruch M.D.*, Jörg Heller M.D.*, * Department of Internal Medicine I, University of Bonn, Bonn, Germany." @default.
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- W4238751017 date "2007-01-01" @default.
- W4238751017 modified "2023-09-27" @default.
- W4238751017 title "Reply:" @default.
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- W4238751017 doi "https://doi.org/10.1002/hep.21943" @default.
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