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- W4238768862 abstract "Vasoactive intestinal peptide (VIP) is a small neuropeptide, which exerts pleiotropic functions. Based on its immunomodulatory, secretory, and possibly trophic effects, VIP is a valuable candidate molecule for the management of autoimmune disease. The purpose of this study was to develop a recombinant viral vector capable of directing the expression of functional VIP. The vector rAd5CMVhVIP was constructed and used to infect 293 cells. VIP expression was measured by an ELISA and function was evaluated by measurement of intracellular cAMP formation. rAd5CMVhVIP directed VIP expression and the transgenic VIP elicited a dose-dependent increase of intracellular cAMP, mediated through the VIP receptor VPAC1. This is the first report showing the construction of a recombinant viral vector encoding biologically active VIP." @default.
- W4238768862 created "2022-05-12" @default.
- W4238768862 date "2004-07-01" @default.
- W4238768862 modified "2023-10-14" @default.
- W4238768862 title "Author index" @default.
- W4238768862 doi "https://doi.org/10.1016/s0006-291x(04)01193-3" @default.
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