Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238785005> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4238785005 endingPage "611" @default.
- W4238785005 startingPage "604" @default.
- W4238785005 abstract "Recombinant human GH therapy to children with idiopathic short stature (ISS) increases growth velocity, but its effect on final height (FH) is still uncertain. The aim of this study was to investigate the effect of recombinant human GH on FH of patients with ISS who were treated according to two protocols in comparison to untreated historical controls. In study 1 (n = 24), all patients were treated with 14 IU (4.6 mg)/m2 body surface·wk in the first year; thereafter the dosage was doubled if the growth response was insufficient. In study 2 (n = 34), patients were randomized into three arms: 18 IU (6 mg)/m2·wk; 27 IU (9 mg)/m2·wk; and 18 IU/m2·wk in the first year, followed by 27 IU/m2·wk thereafter. Observed or estimated FH was available for 53 patients. Thirty-four untreated controls from the same centers were available for comparison. Mean FH sd score in GH-treated children was −2.1, vs. −2.4 in controls (−2.4) (NS), but height sd score gain (1.3 vs. 0.7) and the difference between FH and predicted adult height (4.0 vs. 0.8 cm) were significantly greater. The growth response on an initial dosage of 27 IU/m2·wk (6.9 cm) was significantly better than on other regimens (2.8 cm). We conclude that a GH dosage of 27 IU (9 mg)/m2·wk to prepubertal children with ISS leads to a mean FH gain of approximately 7 cm, whereas regimens starting on lower dosages are less efficacious." @default.
- W4238785005 created "2022-05-12" @default.
- W4238785005 creator A5014272144 @default.
- W4238785005 date "2002-02-01" @default.
- W4238785005 modified "2023-10-18" @default.
- W4238785005 title "Final Height Gain by GH Therapy in Children with Idiopathic Short Stature Is Dose Dependent" @default.
- W4238785005 doi "https://doi.org/10.1210/jc.87.2.604" @default.
- W4238785005 hasPublicationYear "2002" @default.
- W4238785005 type Work @default.
- W4238785005 citedByCount "19" @default.
- W4238785005 countsByYear W42387850052012 @default.
- W4238785005 countsByYear W42387850052013 @default.
- W4238785005 countsByYear W42387850052014 @default.
- W4238785005 crossrefType "journal-article" @default.
- W4238785005 hasAuthorship W4238785005A5014272144 @default.
- W4238785005 hasBestOaLocation W42387850051 @default.
- W4238785005 hasConcept C126322002 @default.
- W4238785005 hasConcept C134018914 @default.
- W4238785005 hasConcept C147583825 @default.
- W4238785005 hasConcept C2777871287 @default.
- W4238785005 hasConcept C2778754045 @default.
- W4238785005 hasConcept C2910005497 @default.
- W4238785005 hasConcept C2984496839 @default.
- W4238785005 hasConcept C2994100043 @default.
- W4238785005 hasConcept C3017783442 @default.
- W4238785005 hasConcept C71315377 @default.
- W4238785005 hasConcept C71924100 @default.
- W4238785005 hasConceptScore W4238785005C126322002 @default.
- W4238785005 hasConceptScore W4238785005C134018914 @default.
- W4238785005 hasConceptScore W4238785005C147583825 @default.
- W4238785005 hasConceptScore W4238785005C2777871287 @default.
- W4238785005 hasConceptScore W4238785005C2778754045 @default.
- W4238785005 hasConceptScore W4238785005C2910005497 @default.
- W4238785005 hasConceptScore W4238785005C2984496839 @default.
- W4238785005 hasConceptScore W4238785005C2994100043 @default.
- W4238785005 hasConceptScore W4238785005C3017783442 @default.
- W4238785005 hasConceptScore W4238785005C71315377 @default.
- W4238785005 hasConceptScore W4238785005C71924100 @default.
- W4238785005 hasIssue "2" @default.
- W4238785005 hasLocation W42387850051 @default.
- W4238785005 hasOpenAccess W4238785005 @default.
- W4238785005 hasPrimaryLocation W42387850051 @default.
- W4238785005 hasRelatedWork W2005170220 @default.
- W4238785005 hasRelatedWork W2009766761 @default.
- W4238785005 hasRelatedWork W2053292707 @default.
- W4238785005 hasRelatedWork W2057820611 @default.
- W4238785005 hasRelatedWork W2144496218 @default.
- W4238785005 hasRelatedWork W2157270853 @default.
- W4238785005 hasRelatedWork W2351281197 @default.
- W4238785005 hasRelatedWork W2356458591 @default.
- W4238785005 hasRelatedWork W2357302135 @default.
- W4238785005 hasRelatedWork W2997792830 @default.
- W4238785005 hasVolume "87" @default.
- W4238785005 isParatext "false" @default.
- W4238785005 isRetracted "false" @default.
- W4238785005 workType "article" @default.